Medicine and Health Sciences Commons^™

Malignant Hyperthermia, Christina Bensley

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia

Christina Bensley

Department of Nursing, Otterbein University

NURS 6810: Advanced Pathophysiology for the Advanced Practice Nurse

Dr. Batross and Dr. Bhatnagar

August 5th, 2022

Abstract

Malignant Hyperthermia (MH) is a rare genetic mutation of the skeletal muscle that induces a hypermetabolic response when patients are exposed to volatile inhaled anesthetics or depolarizing neuromuscular blockers (Weant & Gregory, 2021). The first case of MH was identified in 1960, with an estimated mortality rate of 70-80% without appropriate treatment (Hopkins et al., 2021). Perioperative care providers must be able to identify triggering agents, recognize presenting signs and symptoms, and know …

Perioperative Malignant Hyperthermia, Mitchell Mccorkle

Nursing Student Class Projects (Formerly MSN)

Abstract

Malignant Hyperthermia (MH) is a rare inherited disorder in which exposure to triggering agents such as volatile anesthetics or depolarizing neuromuscular blockers causes a hypermetabolic reaction leading to patient fatality. MH susceptible patients have a genetic mutation on the ryanodine one receptor (RYR1) in skeletal muscle, allowing uninhibited calcium release (Smith, Tranovich, & Ebraheim, 2018). Increases in free calcium result in an uncontrollable sustained muscle contraction through the excitation-contraction coupling of myosin and actin. Sustained muscle contraction rapidly consumes adenosine triphosphate stores and stimulates conversion to lactate producing anaerobic metabolism (Smith et al., 2018). Immediate recognition and treatment of …

Malignant Hyperthermia, Brennon Pinion

Nursing Student Class Projects (Formerly MSN)

Malignant Hyperthermia is a rare but potentially fatal disorder that is triggered by the use of certain anesthetic medications. It is caused by a mutation in specific proteins in skeletal muscle that causes prolonged contraction, leading to a hypermetabolic state. This condition can have deadly effects like kidney failure, hemodynamic instability, and cardiac arrest. It is normally discovered during surgery and must be treated right away. The discovery of the treatment of Malignant Hyperthermia has dramatically decreased the fatality of the disorder, but treatment must be given immediately. For patients who develop Malignant Hyperthermia to have the highest chance of …