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Dna Methylation Patterns In Cord Blood Of Neonates Across Gestational Age Association With Cell-Type Proportions, Susan M. Braid, Kwame Okrah, Amol Shetty, Hector Corrada Bravo
Dna Methylation Patterns In Cord Blood Of Neonates Across Gestational Age Association With Cell-Type Proportions, Susan M. Braid, Kwame Okrah, Amol Shetty, Hector Corrada Bravo
Nursing Faculty Publications
Background: A statistical methodology is available to estimate the proportion of cell types (cellular heterogeneity) in adult whole blood specimens used in epigenome-wide association studies (EWAS). However, there is no methodology to estimate the proportion of cell types in umbilical cord blood (also a heterogeneous tissue) used in EWAS.
Objectives: The objectives of this study were to determine whether differences in DNA methylation (DNAm) patterns in umbilical cord blood are the result of blood cell type proportion changes that typically occur across gestational age and to demonstrate the effect of cell type proportion confounding by comparing preterm infants exposed and …