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Vitamin D Supplementation For The Treatment Of Depressive Symptoms In Women With Type 2 Diabetes: A Randomized Clinical Trial, Sue Penckofer Phd, Monique Ridosh, William Howard Adams, Meghan Grzesiak, Jennifer Woo, Mary Byrn, Joanne Kouba Phd, Rdn, Ldn, Patricia M. Sheean, Colleen Kordish, Ramon Durazo-Arvizu, Diane Wallis, Mary Ann Emanuele, Angelos Halaris

Nursing: School of Nursing Faculty Publications and Other Works

Aim. To determine the efficacy and safety of vitamin D₃ supplementation in reducing depressive symptoms in women with type 2 diabetes (T2D), depression, and low vitamin D. Methods. In this double-blind randomized active comparator-controlled trial, women with significant depressive symptoms as assessed by the Center for Epidemiologic Studies Depression (CES-D) scale received weekly oral vitamin D₃ supplementation (50,000 IU) or an active comparator (5,000 IU) for 6 months. Assessments of vitamin D, 25-hydroxyvitamin D [25 (OH) D], and depression were measured at baseline, 3 months, and 6 months. Results. A total of 129 women were …