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Full-Text Articles in Medicine and Health Sciences
Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray
Description Of The Methodology Used In An Ongoing Pediatric Care Interventional Study Of Children Born With Cleft Lip And Palate In South America [Nct00097149, G. L. Wehby, E. E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, Ann Marie Mccarthy, G. Bobashev, S. Litavecz, A. Mariona, G. Dutra, J. S. Lopez-Camelo, I. M. Orioli, J. C. Murray
Ann Marie McCarthy
BACKGROUND: The contribution of birth defects, including cleft lip and palate, to neonatal and infant mortality and morbidity is substantial. As other mortality and morbidity causes including infections, hygiene, prematurity, and nutrition are eradicated in less developed countries, the burden of birth defects will increase proportionally. METHODS/DESIGN: We are using cleft lip and palate as a sentinel birth defect to evaluate its burden on neonatal and infant health and to assess the effectiveness of systematic pediatric care during the first month and first two years of life in decreasing this burden. The neonatal intervention, consisting of weekly pediatric evaluation and …
A Randomized Trial Of Heparin And Saline For Maintaining Intravenous Locks In Neonates, J. Heilskov, Charmaine Kleiber, K. Johnson, J. Miller
A Randomized Trial Of Heparin And Saline For Maintaining Intravenous Locks In Neonates, J. Heilskov, Charmaine Kleiber, K. Johnson, J. Miller
Charmaine Kleiber
PURPOSE: To determine the effects of saline, heparin 2 units (U) per ml saline, and heparin 10 U/ml saline flush solutions on the duration of intravenous (i.v.) locks and the incidence of i.v. infiltration in neonates. DESIGN: Randomized double-blind experiment. SETTING: Tertiary-care nursery. PARTICIPANTS: Neonates (N = 90) hospitalized at birth in the intensive, intermediate care, or newborn units. MAIN OUTCOME MEASURES: Total hours from the time the i.v. was inserted to the time the i.v. was removed; hours from the time the i.v. was first flushed to the time the i.v. was removed; number of i.vs. removed because of …
Genetic Determinants Of Facial Clefting: Analysis Of 357 Candidate Genes Using Two National Cleft Studies From Scandinavia, A. Jugessur, M. Shi, H. K. Gjessing, R. T. Lie, A. J. Wilcox, C. R. Weinberg, K. Christensen, A. L. Boyles, Sandra Daack-Hirsch, T. N. Trung, C. Bille, A. C. Lidral, J. C. Murray
Genetic Determinants Of Facial Clefting: Analysis Of 357 Candidate Genes Using Two National Cleft Studies From Scandinavia, A. Jugessur, M. Shi, H. K. Gjessing, R. T. Lie, A. J. Wilcox, C. R. Weinberg, K. Christensen, A. L. Boyles, Sandra Daack-Hirsch, T. N. Trung, C. Bille, A. C. Lidral, J. C. Murray
Sandra Daack-Hirsch
BACKGROUND: Facial clefts are common birth defects with a strong genetic component. To identify fetal genetic risk factors for clefting, 1536 SNPs in 357 candidate genes were genotyped in two population-based samples from Scandinavia (Norway: 562 case-parent and 592 control-parent triads; Denmark: 235 case-parent triads). METHODOLOGY/PRINCIPAL FINDINGS: We used two complementary statistical methods, TRIMM and HAPLIN, to look for associations across these two national samples. TRIMM tests for association in each gene by using multi-SNP genotypes from case-parent triads directly without the need to infer haplotypes. HAPLIN on the other hand estimates the full haplotype distribution over a set of …