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Full-Text Articles in Medicine and Health Sciences
Nursing Spirit, Volume 1 (Spring 2016), Neal Chambler, Dean, Mary Bennett, Director, Susan Megahee, Editor, Creative
Nursing Spirit, Volume 1 (Spring 2016), Neal Chambler, Dean, Mary Bennett, Director, Susan Megahee, Editor, Creative
School of Nursing Publications
No abstract provided.
Decreased Interleukin-4 Release From The Neurons Of The Locus Coeruleus In Response To Immobilization Stress, Hyun-Ju Lee, Hyun-Jung Park, Angela Starkweather, Kyungeh An, Insop Shim
Decreased Interleukin-4 Release From The Neurons Of The Locus Coeruleus In Response To Immobilization Stress, Hyun-Ju Lee, Hyun-Jung Park, Angela Starkweather, Kyungeh An, Insop Shim
School of Nursing Publications
It has been demonstrated that immobilization (IMO) stress affects neuroimmune systems followed by alterations of physiology and behavior. Interleukin-4 (IL-4), an anti-inflammatory cytokine, is known to regulate inflammation caused by immune challenge but the effect of IMO on modulation of IL-4 expression in the brain has not been assessed yet. Here, it was demonstrated that IL-4 was produced by noradrenergic neurons in the locus coeruleus (LC) of the brain and release of IL-4 was reduced in response to IMO. It was observed that IMO groups were more anxious than nontreated groups. Acute IMO (2 h/day, once) stimulated secretion of plasma …