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Full-Text Articles in Medicine and Health Sciences
The Genetic Relationship Between Peripheral Inflammation And Alzheimer’S Disease, Davis Cammann
The Genetic Relationship Between Peripheral Inflammation And Alzheimer’S Disease, Davis Cammann
UNLV Theses, Dissertations, Professional Papers, and Capstones
Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and has become an ever-present problem in aging populations. An increasing body of evidence suggests that neuroinflammation is one of the key drivers of AD pathology. One overlooked contributor to this burden is peripheral inflammation throughout the body. Due to increased permeability of the blood-brain-barrier (BBB) in older age, inflammatory plasma proteins and immune cells infiltrate the CNS and drive neuroinflammation through interactions with neurons and glia. In addition, age-related changes in the composition of gut microbiome taxa lead to increased gut permeability and inflammatory burden. Because inflammatory factors are …
Systems Dynamics Of The Anterior Cingulate Cortex And Hippocampus In Behavioral Switching, Spatial Working Memory, And Disease, Ryan Wirt
UNLV Theses, Dissertations, Professional Papers, and Capstones
The electrophysiological properties of the hippocampus (HC) and anterior cingulate cortex (ACC) are the central focus of research on learning, memory, and neurological disease. Previous research has shown that HC is essential for forming new memories, spatial navigation, and temporal processing. While the function of ACC, located within the medial prefrontal cortex, remains controversial, it has a role in long-term memory recall, processing pain, monitoring current state, learning, schema updates, and information integrations. Interactions between the ACC and HC occur during social memory, spatial working memory performance, and long-term memory recall. Notably, the HC and ACC are among the first …