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Changes In The Cholinergic, Catecholaminergic, Orexinergic And Serotonergic Structures Forming Part Of The Sleep Systems Of Adult Mice Exposed To Intrauterine Alcohol, Oladiran I. Olateju, Adhil Bhagwandin, Amadi O. Ihunwo, Paul R. Manger
Changes In The Cholinergic, Catecholaminergic, Orexinergic And Serotonergic Structures Forming Part Of The Sleep Systems Of Adult Mice Exposed To Intrauterine Alcohol, Oladiran I. Olateju, Adhil Bhagwandin, Amadi O. Ihunwo, Paul R. Manger
Brain and Mind Institute
We examined the effect of chronic prenatal alcohol exposure on certain neuronal systems involved with the sleep-wake cycle of C57BL/6J mice exposed to prenatal alcohol once they had reached 56 days post-natal. Pregnant mice were exposed to alcohol, through oral gavage, on gestational days 7–16, with recorded blood alcohol concentration (BAC)s averaging 1.84 mg/ml (chronic alcohol group, CA). Two control groups, an oral gavage sucrose control group (chronic alcohol control group, CAc) and a non-treated control group (NTc), were also examined. At 56 days post-natal, the pups from each group were sacrificed and the whole brain sectioned in a coronal …