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Full-Text Articles in Medicine and Health Sciences

Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown Aug 2023

Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown

Electronic Theses and Dissertations

This dissertation is an examination of spinal cord injury induced neuroplasticity and tests whether noninvasive gene therapy can successfully target neurons in the lumbar spinal cord. It begins with an overview of neural control of locomotion and a brief summary of therapeutics that are used and/or in development for treating spinal anatomically characterize s subset of neurons in the spinal cord, long ascending propriospinal neurons, that are involved in interlimb coordination. Characterization of these neurons allows for subsequent evaluation of their potential involvement in injury induced neuroplasticity. This dissertation is divided into five chapters, covering spinal cord injury and therapeutics. …


On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist Jul 2023

On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist

Electronic Theses and Dissertations

The unique set of impairments and limitations presented by students with autism spectrum disorder (ASD) make the accessing of campus-based nonacademic resources more difficult and complicated than their typically developed peers. Each year, the rate of students entering college with disabilities continues to grow, but their mental well-being is relatively poor. The purpose of this qualitative case study was to apply the conceptual framework of the Andersen behavioral model of health services use (ABMHSU) to the experiences of college students with ASD to understand and predict their utilization of campus-provided mental health resources. The participants were seven college students with …


Temporospatial Characteristics Of The Effect Of A Sound On The Response To Another Sound In Neurons In The Rat Auditory Midbrain, Olivia Elizabeth Sauvé Jun 2023

Temporospatial Characteristics Of The Effect Of A Sound On The Response To Another Sound In Neurons In The Rat Auditory Midbrain, Olivia Elizabeth Sauvé

Electronic Theses and Dissertations

The soundscape of a natural environment can often contain multiple complex sounds, which are perceived binaurally, i.e., by both ears. Under such conditions, the perception of one sound can be affected by another sound. This study was conducted to find the neural basis of such a perceptual phenomenon. The rat is used as an animal model. Action potentials were recorded from individual neurons within the rat inferior colliculus in response to acoustic stimulation. The inferior colliculus is an auditory midbrain structure which receives converging inputs from many other structures along the auditory pathway. It plays a significant role in the …


Toward A Comprehensive Account Of Orientation Selectivity In The Retina., Megan Zipperer May 2023

Toward A Comprehensive Account Of Orientation Selectivity In The Retina., Megan Zipperer

Electronic Theses and Dissertations

Retinal Ganglion Cells (RGCs) form functionally distinct signaling channels that selectively encode features of the visual input including direction of motion, contrast polarity, size, and color. A highly conserved visual channel amongst vertebrates conveys orientation selectivity, i.e., the selective firing of neuronal cells in response to elongated stimuli along a preferred orientation. Orientation selectivity is an apparent critical computation and several studies have reported aspects of it, including cell type identity in anatomical reconstructions, and functional characterization of at least four different identified RGC types. But how cell types in the different studies relate is not well resolved; the mechanisms …