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Learning Deficits And Attenuated Adaptive Stress Response After Early-Life Seizures In Zebrafish., Harsimran Singh, Alfonsina Ramon, Dana Finore, Kaleigh Burnham, Scott Mcrobert, Jocelyn Lippman-Bell
Learning Deficits And Attenuated Adaptive Stress Response After Early-Life Seizures In Zebrafish., Harsimran Singh, Alfonsina Ramon, Dana Finore, Kaleigh Burnham, Scott Mcrobert, Jocelyn Lippman-Bell
PCOM Scholarly Papers
Early-life seizures (ELS) are often associated with the development of cognitive deficits. However, methods to predict and prevent these deficits are lacking. To increase the range of research models available to study cognitive consequences of ELS, we investigated whether seizures in larval zebrafish (Danio rerio) lead to behavioral deficits later in life. We thus modified the existing pentylenetetrazole (PTZ)-induced seizure model in larval zebrafish, exposing zebrafish to PTZ daily from 5 to 7 days post-fertilization (dpf). We then compared later-life learning, social behavior (shoaling), and behavioral and chemical measures of anxiety in the PTZ-exposed zebrafish (PTZ group) to …