Open Access. Powered by Scholars. Published by Universities.®
Alzheimer Disease/metabolism/*physiopathology;; Brain/*metabolism/*physiopathology;; Brain Mapping;; Disease;; Female;; *Health;; Humans;; Magnetic Resonance Imaging;; Male;; Middle Aged;; Motor Activity;; Nerve Net/*physiopathology;; Parkinson Disease/metabolism/*physiopathology;; Positron-Emission Tomography;; Principal Component Analysis;; *Rest;; Task Performance and Analysis;; Pet;; default mode network;; neurodegeneration;; resting state networks
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Metabolic Resting-State Brain Networks In Health And Disease, P. G. Spetsieris, J. H. Ko, C. C. Tang, A. Nazem, W. Sako, S. Peng, Y. Ma, V. Dhawan, D. Eidelberg
Metabolic Resting-State Brain Networks In Health And Disease, P. G. Spetsieris, J. H. Ko, C. C. Tang, A. Nazem, W. Sako, S. Peng, Y. Ma, V. Dhawan, D. Eidelberg
Journal Articles
The delineation of resting state networks (RSNs) in the human brain relies on the analysis of temporal fluctuations in functional MRI signal, representing a small fraction of total neuronal activity. Here, we used metabolic PET, which maps nonfluctuating signals related to total activity, to identify and validate reproducible RSN topographies in healthy and disease populations. In healthy subjects, the dominant (first component) metabolic RSN was topographically similar to the default mode network (DMN). In contrast, in Parkinson's disease (PD), this RSN was subordinated to an independent disease-related pattern. Network functionality was assessed by quantifying metabolic RSN expression in cerebral blood …