Open Access. Powered by Scholars. Published by Universities.®
Alarmins;; HMGB1;; immunomodulation;; myeloid-derived suppressor cell;; RAGE;; stroke;; mobility group box-1;; stroke-induced immunodepression;; cerebral-artery;; occlusion;; regulatory t-cells;; lymphocyte subsets;; suppressor-cells;; nervous-system;; ischemic brain;; hmgb1;; activation;; Neurosciences & Neurology
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Damp Signaling Is A Key Pathway Inducing Immune Modulation After Brain Injury, A. Liesz, A. Dalpke, E. Mracsko, D. J. Antoine, S. Roth, W. Zhou, H. Yang, P. P. Nawroth, K. J. Tracey, R. Veltkamp, +4 Additional Authors
Damp Signaling Is A Key Pathway Inducing Immune Modulation After Brain Injury, A. Liesz, A. Dalpke, E. Mracsko, D. J. Antoine, S. Roth, W. Zhou, H. Yang, P. P. Nawroth, K. J. Tracey, R. Veltkamp, +4 Additional Authors
Journal Articles
Acute brain lesions induce profound alterations of the peripheral immune response comprising the opposing phenomena of early immune activation and subsequent immunosuppression. The mechanisms underlying this brain-immune signaling are largely unknown. We used animal models for experimental brain ischemia as a paradigm of acute brain lesions and additionally investigated a large cohort of stroke patients. We analyzed release of HMGB1 isoforms by mass spectrometry and investigated its inflammatory potency and signaling pathways by immunological in vivo and in vitro techniques. Features of the complex behavioral sickness behavior syndrome were characterized by homecage behavior analysis. HMGB1 downstream signaling, particularly with RAGE, …