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Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
Down-Regulation Of Cyclin D2 In Amyloid Β Toxicity, Inflammation, And Alzheimer’S Disease, Joanna B. Strosznajder, Grzegorz A. Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J. Lukiw
Down-Regulation Of Cyclin D2 In Amyloid Β Toxicity, Inflammation, And Alzheimer’S Disease, Joanna B. Strosznajder, Grzegorz A. Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J. Lukiw
School of Medicine Faculty Publications
In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid precursor protein (βAPP), wild-type (APPwt-PC12), or carrying the Swedish mutantion (APPsw-PC12); (ii) the murine hippocampus during SIR; and (iii) Alzheimer’s disease (AD) brain. In APPwtPC12 expression of cyclin D2 (cD2) was exclusively reduced, and in APPsw-PC12 cyclins cD2 and also cA1 were down-regulated, but cA2, cB1, cB2, and cE1 were up-regulated. In the SIR cD2, cB2, cE1 were found to be significantly …
Muscle Selection And Dosing In A Phase 3, Pivotal Study Of Abobotulinumtoxina Injection In Upper Limb Muscles In Children With Cerebral Palsy, Joyce Oleszek, Ann Tilton, Jorge Carranza Del Rio, Nigar Dursun, Marcin Bonikowski, Edward Dabrowski, Simon Page, Benjamin Regnault, Catherine Thompson, Mauricio R. Delgado
Muscle Selection And Dosing In A Phase 3, Pivotal Study Of Abobotulinumtoxina Injection In Upper Limb Muscles In Children With Cerebral Palsy, Joyce Oleszek, Ann Tilton, Jorge Carranza Del Rio, Nigar Dursun, Marcin Bonikowski, Edward Dabrowski, Simon Page, Benjamin Regnault, Catherine Thompson, Mauricio R. Delgado
School of Medicine Faculty Publications
Background: Guidelines recommend botulinum toxin-A in pediatric upper limb spasticity as part of routine practice. Appropriate dosing is a prerequisite for treatment success and it is important that injectors have an understanding on how to tailor dosing within a safe and effective range. We report upper limb dosing data from a phase 3 study of abobotulinumtoxinA injections in children with cerebral palsy. Methods: This was a double-blind, repeat-treatment study (NCT02106351). In Cycle 1, children were randomized to abobotulinumtoxinA at 2 U/kg control dose or clinically relevant 8 U/kg or 16 U/kg doses. Doses were divided between the primary target muscle …
Prophylactic Antibiotics Do Not Prevent Cns Infection In Civilian Gunshotwounds To The Head, Olivia E. Gilbert, Adam G. Podet, Ellery A. Hayden, John M. Wilson, Clifford Crutcher, Gabriel C. Tender
Prophylactic Antibiotics Do Not Prevent Cns Infection In Civilian Gunshotwounds To The Head, Olivia E. Gilbert, Adam G. Podet, Ellery A. Hayden, John M. Wilson, Clifford Crutcher, Gabriel C. Tender
Medical Student Research Poster Symposium
Introduction: Civilian gunshot wounds to the head (GSWH) are an ongoing epidemic in the US, with incidence rising each year. They are frequently devastating, with case fatality rates approaching 91%, accounting for fatalities occurring in the hospital and at the scene of injury. Although military GSWH are robust, data and management guidelines for civilian GSWH is relatively lacking. Specifically, the administration of prophylactic antibiotics in GSWH patients remains controversial. Prior studies indicate the incidence of intracranial infection after civilian GSWH to be as high as 25%, with significant impact on morbidity and mortality. Objective: To assess the factors that increase …
The Effects Of Cognitive Impairment And Brain Atrophy On The Development Of Depressionin Patients With Multiple Sclerosis, Caitlyn Kelly, Jaeyeon Kweon, Carrie Pham, Shannin Moody, Deidre Devier
The Effects Of Cognitive Impairment And Brain Atrophy On The Development Of Depressionin Patients With Multiple Sclerosis, Caitlyn Kelly, Jaeyeon Kweon, Carrie Pham, Shannin Moody, Deidre Devier
Medical Student Research Poster Symposium
Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease characterized by the demyelination of axons within the central nervous system leading to the development of motor, sensory, and cognitive deficits. The cognitive impairment present in people with MS typically presents as deficits in complex attention, memory, and planning. 25- 50% of patients with MS will develop depressive symptoms during the course of their disease. Depression can also affect aspects of cognition, particularly executive functioning, which can mimic the cognitive deficits seen in patients with MS. Previous studies have found that depressive symptoms appear more often in patients in the later …
Parkinson’S Disease And Miro1 As A Potential Marker, David Nguyen, Vinita Bharat, Devon M. Conradson, Pawan Nandakishore, Xinnan Wang
Parkinson’S Disease And Miro1 As A Potential Marker, David Nguyen, Vinita Bharat, Devon M. Conradson, Pawan Nandakishore, Xinnan Wang
Medical Student Research Poster Symposium
Background: Miro1 is an outer mitochondrial membrane protein that recruits microtubule motors to mitochondria to mediate their transport. Miro1 is removed from the surface of depolarized mitochondria to arrest their motility and to facilitate their subsequent clearance via mitophagy. The molecular players that mediate Miro1 removal from damaged mitochondria include Parkinson’s-related (PD) proteins—LRRK2, PINK1, and Parkin. Mutations in LRRK2, PINK1, or Parkin cause familial PD and are also associated with the risk of sporadic PD. Therefore, mitophagy may play a key role in Parkinson’s pathogenesis and in additional age- dependent neurodegenerative diseases. We have previously found that Miro1 is resistant …
Education Level Moderates The Effect Of Brain Atrophy On Cognition Inmultiple Sclerosis, Carrie Pham, Caitlyn Kelly, Jaeyeon Kweon, Jesus Lovera, Deidre Devier
Education Level Moderates The Effect Of Brain Atrophy On Cognition Inmultiple Sclerosis, Carrie Pham, Caitlyn Kelly, Jaeyeon Kweon, Jesus Lovera, Deidre Devier
Medical Student Research Poster Symposium
The cognitive reserve theory refers to how clinical manifestations of brain pathology are affected by the brain’s ability to use preexisting cognitive processes to cope with and adapt to neurological insult or damage. Studies suggest that greater intellectual ability leading to greater educational attainment may attenuate the negative cognitive effects of brain atrophy by increasing cognitive reserve, protecting against cognitive impairment. Based on this theory, we were interested in seeing if the cognitive effects of brain atrophy, measured by the third ventricle width (TVW), would be attenuated in people with multiple sclerosis (MS) who had more than 12 years of …
Combined Therapy With Avastin, A Paf Receptor Antagonist And A Lipid Mediator Inhibited Glioblastoma Tumor Growth, Valerie A. Cruz Flores, Hemant Menghani, Pranab K. Mukherjee, Luis Marrero, Andre Obenaus, Quan Dang, Larissa Khoutorova, Madigan M. Reid, Ludmila Belayev, Nicolas G. Bazan
Combined Therapy With Avastin, A Paf Receptor Antagonist And A Lipid Mediator Inhibited Glioblastoma Tumor Growth, Valerie A. Cruz Flores, Hemant Menghani, Pranab K. Mukherjee, Luis Marrero, Andre Obenaus, Quan Dang, Larissa Khoutorova, Madigan M. Reid, Ludmila Belayev, Nicolas G. Bazan
School of Medicine Faculty Publications
Glioblastoma multiforme (GBM) is an aggressive, highly proliferative, invasive brain tumor with a poor prognosis and low survival rate. The current standard of care for GBM is chemotherapy combined with radiation following surgical intervention, altogether with limited efficacy, since survival averages 18 months. Improvement in treatment outcomes for patients with GBM requires a multifaceted approach due to the dysregulation of numerous signaling pathways. Recently emerging therapies to precisely modulate tumor angiogenesis, inflammation, and oxidative stress are gaining attention as potential options to combat GBM. Using a mouse model of GBM, this study aims to investigate Avastin (suppressor of vascular endothelial …
Rupture Of A Superficial Temporal Artery Pseudoaneurysm Following Craniotomy, Jessica A. Shields, Jared M. Robichaux, Kevin Morrow, Clifford Crutcher, Gabriel Tender
Rupture Of A Superficial Temporal Artery Pseudoaneurysm Following Craniotomy, Jessica A. Shields, Jared M. Robichaux, Kevin Morrow, Clifford Crutcher, Gabriel Tender
School of Medicine Faculty Publications
Pseudoaneurysm of the superficial temporal artery (STA) is a rare entity that has been reported in the literature after trauma or iatrogenic injuries. We describe a unique case of STA pseudoaneurysm rupture and the clinical sequelae associated with its rupture. We report a case of pseudoaneurysm rupture of the STA that occurred 14 days after craniotomy for cerebrospinal fluid leak repair. We also review the literature, diagnosis and treatment of external carotid artery aneurysms. Rupture of a STA pseudoaneurysm is a previously unreported and serious complication that must be quickly recognized in order to control hemorrhage that may have life …
Microrna-146a-5p, Neurotropic Viral Infection And Prion Disease (Prd), Aileen I. Pogue, Walter J. Lukiw
Microrna-146a-5p, Neurotropic Viral Infection And Prion Disease (Prd), Aileen I. Pogue, Walter J. Lukiw
School of Graduate Studies Faculty Publications
The human brain and central nervous system (CNS) harbor a select sub-group of potentially pathogenic microRNAs (miRNAs), including a well-characterized NF-kB-sensitive Homo sapiens microRNA hsa-miRNA-146a-5p (miRNA-146a). miRNA-146a is significantly over-expressed in progressive and often lethal viral- and prion-mediated and related neurological syndromes associated with progressive inflammatory neurodegeneration. These include ~18 different viral-induced encephalopathies for which data are available, at least ~10 known prion diseases (PrD) of animals and humans, Alzheimer’s disease (AD) and other sporadic and progressive age-related neurological disorders. Despite the apparent lack of nucleic acids in prions, both DNA- and RNA-containing viruses along with prions significantly induce miRNA-146a …
Regulation Of Microrna Expression In Sleep Disorders In Patients With Epilepsy, Edyta Dziadkowiak, Justyna Chojdak-Łukasiewicz, Piotr Olejniczak, Bogusław Paradowski
Regulation Of Microrna Expression In Sleep Disorders In Patients With Epilepsy, Edyta Dziadkowiak, Justyna Chojdak-Łukasiewicz, Piotr Olejniczak, Bogusław Paradowski
School of Medicine Faculty Publications
The effects of epilepsy on sleep and the activating effects of sleep on seizures are well documented in the literature. To date, many sleep-related and awake-associated epilepsy syndromes have been described. The relationship between sleep and epilepsy has led to the recognition of polysomnographic testing as an important diagnostic tool in the diagnosis of epilepsy. The authors analyzed the available medical database in search of other markers that assess correlations between epilepsy and sleep. Studies pointing to microRNAs, whose abnormal expression may be common to epilepsy and sleep disorders, are promising. In recent years, the role of microRNAs in the …
Emergency Use Of Targeted Osmotic Lysis For The Treatment Of A Patient With Aggressive Late-Stage Squamous Cell Carcinoma Of The Cervix, Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul
Emergency Use Of Targeted Osmotic Lysis For The Treatment Of A Patient With Aggressive Late-Stage Squamous Cell Carcinoma Of The Cervix, Harry J. Gould, Paige R. Miller, Samantha Edenfield, Kelly Jean Sherman, Chad K. Brady, Dennis Paul
School of Medicine Faculty Publications
Upregulation of voltage-gated sodium channels (VGSCs) and Na+/K+-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
Neurological Complications Of Covid19 During March 2020 At Lcmc Health University Medical Center: Dataset, David Chachkhiani, Michael Y. Soliman, Delphi Barua, Marine Isakadze, Nicole R. Villemarette-Pittman, Deidre J. Devier, Jesus F. Lovera
Neurological Complications Of Covid19 During March 2020 At Lcmc Health University Medical Center: Dataset, David Chachkhiani, Michael Y. Soliman, Delphi Barua, Marine Isakadze, Nicole R. Villemarette-Pittman, Deidre J. Devier, Jesus F. Lovera
School of Medicine Faculty Publications
We reviewed the electronic medical records (EMR) of patients hospitalized during the peak of the pandemic, March 1st through March 31st, to document the type and frequency of neurological problems seen in patients with COVID-19 at presentation to the emergency room. Secondary aims were to determine: 1) the frequency of neurological complaints during the hospital stay; 2) whether the presence of any neurological complaint at presentation or any of the individual types of neurological complaints at admission predicted three separate outcomes: death, length of hospital stay, or the need for intubation; and 3) if the presence of any neurological complaint …