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Synthesis Of A Nanoscale Gold-Coated, Thermoresponsive Molecular Release System., Ryan C. Weegens
Synthesis Of A Nanoscale Gold-Coated, Thermoresponsive Molecular Release System., Ryan C. Weegens
College of Arts & Sciences Senior Honors Theses
The work presented here was performed in conjunction with an experimental group in order to prove the concept that an alternating magnetic field (AMF) could be used to induce an intramolecular cyclization to effect payload release. The system studied here consisted of a fluorophore tethered to gold-coated iron oxide nanoparticles (Fe3O4 NPs) via an organic linker consisting of 2 key elements: a carbonate (electrophile) and an amine (nucleophile). Connected to the carbonate was the fluorophore, anthracene, which was attached to the organic linker system by means of an oxime ether linkage. This thesis work served as the …