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Full-Text Articles in Medicine and Health Sciences
Investigation Of Genomic Instability Induced By G-Quadruplexes In The Absence Of Functional Topoisomerase 1 In Yeast, Alexandra Berroyer
Investigation Of Genomic Instability Induced By G-Quadruplexes In The Absence Of Functional Topoisomerase 1 In Yeast, Alexandra Berroyer
Dissertations & Theses (Open Access)
Topoisomerase 1 (Top1) is an enzyme that removes transcriptionally generated negative supercoils by binding and nicking DNA. Since transcription of guanine-rich DNA leads to the formation of G-quadruplex (G4) structures, Top1’s function likely suppresses G4-formation. In support of this, Top1 significantly reduces co-transcriptional G4 DNA-associated genomic instability at a model G4-motif in Saccharomyces cerevisiae. However, whether Top1 suppresses G4-formation on a genome-wide scale in yeast remains unexplored. Therefore, I aimed to uncover if deletion of Top1 enhances genome-wide G4-formation in S. cerevisiae. As an approach to quantify global G4-formation, I expressed the G4-specific antibody BG4 from a yeast …
The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, Nicole Stephens
The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, Nicole Stephens
Dissertations & Theses (Open Access)
Poor oral health is a predictor of cognitive decline in elderly populations and has been shown to precede dementia. As cognitive decline progresses, patients are likely to move from the community into nursing facilities. We hypothesize that severity of dementia and residency type will impact the oral health of patients with dementia. Fifty-two participants of two dementia levels were recruited from the UTHealth Neurocognitive Disorders Center and two Houston-area nursing homes. A standardized oral health assessment, plaque index, and oral bacteria analysis determined participants’ oral health status. Further, data was collected on participants’ medical history, oral hygiene habits, dietary habits, …