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Full-Text Articles in Medicine and Health Sciences
Identification And Characterization Of An Interferon Stimulated Gene That Restricts Alphavirus Infection And Pathogenesis, Subhajit Poddar
Identification And Characterization Of An Interferon Stimulated Gene That Restricts Alphavirus Infection And Pathogenesis, Subhajit Poddar
Arts & Sciences Electronic Theses and Dissertations
Viral infection of host cells induces the Type I interferon (IFN) response, which is
characterized by the production of hundreds of IFN-stimulated genes (ISGs). Altogether, these
ISGs function to induce an antiviral state, hindering or blocking various steps of the viral
lifecycle. Many individual ISGs have potent and broad antiviral functions. However elimination
of a single ISG does not completely abrogate protection, suggesting that other ISGs, although
moderate or moderate when considered alone, must work cooperatively to provide optimal
antiviral activity.
In order to identify and characterize novel ISGs, an attenuated strain of the alphavirus
chikungunya (CHIKV-181/25) was tested against …
Expansion Of Microbial Virology By Impetus Of The Reduction Of Viral Dark Matter, Siddharth Ravindran Krishnamurthy
Expansion Of Microbial Virology By Impetus Of The Reduction Of Viral Dark Matter, Siddharth Ravindran Krishnamurthy
Arts & Sciences Electronic Theses and Dissertations
Modern metagenomic methods have rapidly accelerated the rate of viral discovery. Currently, to discover a novel virus, deep sequencing reads must align to a known reference virus. While alignment is effective at identifying closely related viruses, highly divergent viruses can often share no discernable sequence alignment with known viruses. Therefore, the accurate classification of viral dark matter – metagenomic sequences that originate from viruses but do not align to any reference virus sequences – is one of the major obstacles in not only discovering novel viruses, but also by extension, comprehensively defining the virome. As viral dark matter results fundamentally …
The Role Of Bhlhe40 In Autoimmune Neuroinflammation And Mycobacterial Infection, Chih-Chung Lin
The Role Of Bhlhe40 In Autoimmune Neuroinflammation And Mycobacterial Infection, Chih-Chung Lin
Arts & Sciences Electronic Theses and Dissertations
The mammalian immune system is composed of innate and adaptive compartments, which cooperate with each other to maintain homeostasis and protect the host from the invasion by a variety of pathogens. The tight control of immune responses is extremely important for all individuals. Here, we discovered that the transcription factor basic helix-loop-helix family, member e40 (Bhlhe40) is a critical protein that regulates the autoimmune ("against self") and anti-microbial ("against non-self") responses of myeloid cells and T lymphocytes. Multiple sclerosis (MS) is a human neuroinflammatory disease in the central nervous system with an autoimmune etiology. We have reported that Bhlhe40 positively …
The Role Of Histidine Rich Protein Ii In Cerebral Malaria, Priya Pal
The Role Of Histidine Rich Protein Ii In Cerebral Malaria, Priya Pal
Arts & Sciences Electronic Theses and Dissertations
Human malaria is caused by five species of Plasmodium. Of these, P. falciparum is the deadliest and is the only species that causes cerebral malaria (CM). CM is a disease of the vascular endothelium characterized by parasite sequestration, increased inflammatory cytokine production, vascular leakage and leukocyte infiltration. A distinguishing feature of P. falciparum infection is the parasite’s production and secretion of histidine-rich protein II (HRPII). HRPII accumulates to high concentrations (up to 100 µg/ml) in serum, which correlates with disease severity. Due to high serum levels of this protein, HRPII has classically been considered a biomarker for P. falciparum infection. …