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Full-Text Articles in Medicine and Health Sciences
Treating Breast Cancer With Light: The Creation Of Two Photodynamic Therapy Agents, Victoria Lackey
Treating Breast Cancer With Light: The Creation Of Two Photodynamic Therapy Agents, Victoria Lackey
Honors Theses
Photodynamic therapy (PDT) is a treatment for a wide display of diseases, including cancer, that has become gradually widespread. The procedure requires the usage of photosynthesizing agents, which are activated in the presence of light. One quite successful photodynamic therapy agent is an aromatic structure made up of four pyrrole rings called a porphyrin. This research focused on producing the water-soluble porphyrins, H2TPP-3-PEG-OH and H2TPP-PiperMe-OH, through the attachment of the starting porphyrin, H2TPPC, with 3-polyethyleneglycol and 3-piperidinemethanol, respectively. The novel, water-soluble agent was purified and characterized by infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and UV-vis spectroscopy. Purity was …
Seasonal Affective Disorder In Vermont, Hannah Johnson
Seasonal Affective Disorder In Vermont, Hannah Johnson
Family Medicine Clerkship Student Projects
A large proportion of major depression in Vermont has a seasonal pattern. The most common form of Seasonal Affective Disorder is winter depression. Several evidence-based treatments exist for SAD including light therapy, CBT, and antidepressant medications. Adjunct therapies, like exercise and social interaction, can also help patients feel better during the winter. In the primary care setting, an educational handout/poster will aid in educating patients about SAD and treatment options, and encourage them to seek help.