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King Faisal Specialist Hospital & Research Center
Acute lymphoblastic leukemia; Allogeneic stem cell transplantation; BCR-ABL; Haploidentical donor; Ph+ ALL; Philadelphia chromosome
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Effects Of Different Types Of Allogeneic Hematopoietic Stem Cell Transplantation Donors On Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia During The Tyrosine Kinase Inhibitor Era: A Systematic Review And Meta-Analysis, Ben Ponvilawan, Weerapat Owattanapanich, Nipith Charoenngam, Smith Kungwankiattichai
Effects Of Different Types Of Allogeneic Hematopoietic Stem Cell Transplantation Donors On Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia During The Tyrosine Kinase Inhibitor Era: A Systematic Review And Meta-Analysis, Ben Ponvilawan, Weerapat Owattanapanich, Nipith Charoenngam, Smith Kungwankiattichai
Hematology/Oncology and Stem Cell Therapy
Background: Matched donor (MD) allogeneic hematopoietic stem cell transplantation (allo- HSCT) is currently the preferred choice of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients who have achieved complete remission. This systematic review and meta-analysis was conducted to investigate the effects of allo-HSCTs from different donor types for Ph+ ALL patients who received tyrosine kinase inhibitors (TKIs). Methods: Studies in EMBASE and MEDLINE between inception and December 2020 were identified using search terms related to ‘‘Ph+ ALL” and ‘‘HSCT.” Eligible studies were studies with Ph+ ALL patients who received a TKI and allo-HSCT. The primary outcomes of interest—the …