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Distribution Of Helicobacter Pylori Virulence Markers In Patients With Gastroduodenal Diseases In Pakistan., Javed Yakoob, Shahab Abid, Z Abbas, Wasim Jafri, Zubair Ahmad, Rashida Ahmed, Muhammad Islam
Distribution Of Helicobacter Pylori Virulence Markers In Patients With Gastroduodenal Diseases In Pakistan., Javed Yakoob, Shahab Abid, Z Abbas, Wasim Jafri, Zubair Ahmad, Rashida Ahmed, Muhammad Islam
Section of Gastroenterology
BACKGROUND:
Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU).
METHODS:
H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out.
RESULTS:
Two hundred and twenty-four patients were included, 141 …