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Immunomodulatory Effect Of Cytosine-Phosphate-Guanosine (Cpg)-Oligonucleotides In Nonasthmatic Chronic Rhinosinusitis: An Explant Model, L Tan, T Rogers, N Hatzirodos, L Baker, E Ooi, Peter-John Wormald
Immunomodulatory Effect Of Cytosine-Phosphate-Guanosine (Cpg)-Oligonucleotides In Nonasthmatic Chronic Rhinosinusitis: An Explant Model, L Tan, T Rogers, N Hatzirodos, L Baker, E Ooi, Peter-John Wormald
Peter-John Wormald
Background: The use of cytosine-phosphate-guanosine-oligodeoxynucleotides (CpG-ODNs) or immunostimulatory sequences (ISSs) in the treatment of airway diseases is gaining interest. Binding of the CpG-ODN ligand to Toll-like receptor 9 (TLR9) triggers a shift from a Th2- to a Th1-type response in the target tissue. In this study, we explored the potential use of CpG-ODN to dampen the predominantly Th2-driven chronic inflammatory state in our cohort of patients. Methods: An in vitro explant model comprising of sinonasal tissue from patients with asthma (n=12) and without asthma (n=11) were stimulated with CpG-ODN or Staphylococcus aureus enterotoxin B (SEB) or CpG-ODN in combination with …