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Serum Concentrations Of Organochlorine Pesticides And Growth Among Russian Boys, Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan A. Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, Julie T. Del Prato, Olivier Humblet, Donald G. Patterson, Wayman E. Turner, Mikhail Starovoytov, Russ Hauser
Serum Concentrations Of Organochlorine Pesticides And Growth Among Russian Boys, Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan A. Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, Julie T. Del Prato, Olivier Humblet, Donald G. Patterson, Wayman E. Turner, Mikhail Starovoytov, Russ Hauser
Mary M. Lee
Background: Limited human data suggest an association of organochlorine pesticides (OCPs) with adverse effects on children's growth.Objective: We evaluated the associations of OCPs with longitudinally assessed growth among peripubertal boys from a Russian cohort with high environmental OCP levels. Methods: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at 8-9 years of age were followed prospectively for 4 years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height …
Genetic Modification Of The Association Between Peripubertal Dioxin Exposure And Pubertal Onset In A Cohort Of Russian Boys, Olivier Humblet, Susan A. Korrick, Paige L. Williams, Oleg Sergeyev, Claude Emond, Linda S. Birnbaum, Jane S. Burns, Larisa Altshul, Donald G. Patterson Jr., Wayman E. Turner, Mary M. Lee, Boris Revich, Russ Hauser
Genetic Modification Of The Association Between Peripubertal Dioxin Exposure And Pubertal Onset In A Cohort Of Russian Boys, Olivier Humblet, Susan A. Korrick, Paige L. Williams, Oleg Sergeyev, Claude Emond, Linda S. Birnbaum, Jane S. Burns, Larisa Altshul, Donald G. Patterson Jr., Wayman E. Turner, Mary M. Lee, Boris Revich, Russ Hauser
Mary M. Lee
BACKGROUND: Exposure to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies. Whether genetic polymorphisms may modify this association is currently unknown. Identifying such genes could provide insight into mechanistic pathways. This is one of the first studies to assess genetic susceptibility to dioxins. OBJECTIVES: We evaluated whether common polymorphisms in genes affecting either molecular responses to dioxin exposure or pubertal onset influence the association between peripubertal serum dioxin concentration and male pubertal onset. METHODS: In this prospective cohort of Russian adolescent boys (n = 392), we assessed gene-environment interactions for 337 tagging single-nucleotide polymorphisms …