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Full-Text Articles in Medicine and Health Sciences
The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson
The First International Workshop On Multiple Endocrine Neoplasia Type 2 Syndromes, Charles E. Jackson
Henry Ford Hospital Medical Journal
No abstract provided.
The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin
The Calcitonin Assay And Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Footnote, Kenneth E. W. Melvin
Henry Ford Hospital Medical Journal
No abstract provided.
Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten
Central Registration Of Multiple Endocrine Neoplasia Type 2 Families In The Netherlands, C. J. M. Lips, E. Den Aantrekker, J. M. Jansen-Schillhorn Van Veen, R. A. Geerdink, G. Griffioen, E. A. Van Slooten
Henry Ford Hospital Medical Journal
No abstract provided.
Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder
Register Of Multiple Endocrine Neoplasia Type 2 Syndromes In The United Kingdom, Bruce A. J. Ponder
Henry Ford Hospital Medical Journal
A collaborative group for the study of multiple endocrine neoplasia type 2 (MEN-2) syndromes comprised of clinicians and laboratory scientists has been set up in the United Kingdom. Its aims are 1) to provide a basis for collaborative work on MEN-2; 2) to establish a register of patients; 3) and specifically to conduct studies aimed at defining the best policy for screening the families of apparently sporadic patients, to establish radioimmunoassays for family screening, and to identify large kindreds for genetic linkage studies using DNA polymorphisms.
A French Canadian Family With Multiple Endocrine Neoplasia Type 2 Syndromes, Maurice B. Verdy, Marcel Cadotte, Walter Schurch, William C. Sturtridge, Jacques Cantin, Andrée M. Weber, André Lacroix, Cynthia Forster-Gibson
A French Canadian Family With Multiple Endocrine Neoplasia Type 2 Syndromes, Maurice B. Verdy, Marcel Cadotte, Walter Schurch, William C. Sturtridge, Jacques Cantin, Andrée M. Weber, André Lacroix, Cynthia Forster-Gibson
Henry Ford Hospital Medical Journal
No abstract provided.
Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson
Chromosomes In Multiple Endocrine Neoplasia Type 2 Syndromes, Daniel L. Van Dyke, V. Ramesh Babu, Charles E. Jackson
Henry Ford Hospital Medical Journal
In 19 patients from nine MEN-2A families, high-resolution C-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.
Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara
Multiple Endocrine Neoplasia Type 2 Syndromes In Japan, Shin-Ichiro Takai, Akira Miyauchi, Hideo Matsumoto, Tatsuro Ikeuchi, Tetsuro Miki, Kanji Kuma, Yuichi Kumahara
Henry Ford Hospital Medical Journal
Through nationwide surveys, we collected and analyzed 242 patients of medullary thyroid carcinoma (MTC). Included were 40 patients with multiple endocrine neoplasia type 2A (MEN-2A), six patients with MEN-2B, and 36 patients with only MTC having a positive family history (82 total patients in the hereditary group). Ten-year survival rates were 81.5% for all cases, and 97.5% and 76.1% for the hereditary and the sporadic group, respectively. Epinephrine/norepinephrine ratio in the urine was found to be a good indicator of the adrenomedullary hyperfunction in patients with hereditary MTC. At least one patient in each family with hereditary MTC had overt …
Book Review: Medical Meanings, Fred W. Whitehouse
Book Review: Medical Meanings, Fred W. Whitehouse
Henry Ford Hospital Medical Journal
No abstract provided.
Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner
Linkage Data Excluding A Locus For Multiple Endocrine Neoplasia Type 2 Syndromes From The Distal Part Of The Short Arm Of Chromosome 11, Kenneth K. Kidd, Susan D. Kruger, Daniela S. Gerhard, Judith R. Kidd, David Housman, Joseph M. Gertner
Henry Ford Hospital Medical Journal
A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large …
The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz
The Molecular Basis Of Polypeptide Hormone Production By Medullary Thyroid Cancer, C. J. M. Lips, P. H. Steenbergh, J. W. M. Höppener, J. Zandberg, H. S. Jansz
Henry Ford Hospital Medical Journal
Using recombinant DNA techniques, we analyzed the structure of human calcitonin (CT)-encoding DNA. The sequence of nucleotides derived from the messenger RNA (mRNA) predict the amino acid sequence of the entire human CT precursor protein. The complete CT gene could be isolated from a DNA library of the human genome. The CT precursor encoding sequences (exons) as well as the noncoding intervening sequences (introns) could be identified. Another sequence, called human calcitonin gene-related peptide (hCCRP), could be located near this CT-encoding DNA. A genomic fragment encoding hCCRP was used as a probe to detect and isolate the corresponding mRNA in …
Scintigraphy With 1-131 Mibg As An Aid To The Treatment Of Pheochromocytomas In Patients With The Multiple Endocrine Neoplasia Type 2 Syndromes, James C. Sisson, Brahm Shapiro, William H. Beierwaltes
Scintigraphy With 1-131 Mibg As An Aid To The Treatment Of Pheochromocytomas In Patients With The Multiple Endocrine Neoplasia Type 2 Syndromes, James C. Sisson, Brahm Shapiro, William H. Beierwaltes
Henry Ford Hospital Medical Journal
We reviewed the scintigraphic images made after injections of 1-131 metaiodobenzylguanidine (MIBG) or 1-123 MIBG in patients with multiple endocrine neoplasia (MEN) types 2A and 2B. The information we obtained was applied to three questions about the treatment of pheochromocytoma in patients affected with these syndromes. Our first question "When should adrenal gland(s) be removed?" was not directly answered. However, adrenalectomy generally should not be contemplated unless distinct abnormalities are present in the scintigraphic images. With experience it may be possible to approximate, from the stage of pheochromocytoma depicted by scintigraphy, how many years will elapse before symptoms or hypertension …
Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill
Research Vistas In The Multiple Endocrine Neoplasia Syndromes, John J. Mulvihill
Henry Ford Hospital Medical Journal
Progress in understanding the single gene, cytogenetic, and multifactorial traits that predispose to human cancer suggests possible new directions for research in the multiple endocrine neoplasia (MEN) syndromes. Among the other 200 or so monogenic disorders associated with human neoplasia, advances have come from further delineation of syndromes by various clinical specialists, the recognition of subtypes of syndromes previously thought to be homogeneous, the search for in vitro manifestations of the mutant gene in fibroblasts, and the establishment of cell, tissue and patient registries and of voluntary lay organizations to serve as advocates for the disease. With regard to cytogenetics, …
Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple
Multiple Endocrine Neoplasia Type 2 Syndromes: Historical Perspectives, John H. Sipple
Henry Ford Hospital Medical Journal
No abstract provided.
Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander
Impact Of Screening On Prognosis In The Multiple Endocrine Neoplasia Type 2 Syndromes: Natural History And Treatment Results In 105 Patients, Margareta Telenius-Berg, Bertel Berg, Bertil Hamberger, Sten Tibblin, Lars-Erik Tisell, Lars Ysander, Gunnar Welander
Henry Ford Hospital Medical Journal
We evaluated the effects of screening for multiple endocrine neoplasia type 2A (MEN-2A) in 12 families. Genealogical studies going back to 1730 show a common ancestry for seven Swedish families and one American family. The total number of patients included 105 individuals, 68 of whom were diagnosed by our screening program. Our screening methods for medullary carcinoma of the thyroid (MTC) had an optimal sensitivity and specificity. The frequency of gene carriers detected in MEN-2A families was 55%. Screening will lead to early diagnosis and early therapy, which in turn, will significantly decrease morbidity, incidence of surgical complications, and mortality …
Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen
Screening For Hereditary Medullary Cancer In Denmark, Kristian Emmertsen
Henry Ford Hospital Medical Journal
Screening of first-degree relatives of patients with medullary thyroid cancer (MTC) gave normal values of pentagastrin-stimulated serum calcitonin and 24-hour urinary catecholamine levels in the relatives of 18 of 22 patients. This result is considered to be valid evidence for sporadic MTC. Absence of C-cell hyperplasia maybe another indication of sporadic MTC. Four hereditary MTCs were represented by one fully expressed MEN-2B patient without affected relatives, one fully expressed MEN-2A case in one family, and two first cousins with MTC as the only MEN-2A lesion in another family. Fourteen relatives of the MEN-2A patients had elevated serum calcitonin levels, and …
Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio
Familial Medullary Carcinoma Of The Thyroid: Clinical Studies In Northern New England, Walter W. Noll, L. Herbert Maurer, Victoria L. Herzberg, Paul J. Beisswenger, Brian M. Quinn, Charles C. Cate, Jane P. Bassick, Patricia A. Clark, Thomas A. Colacchio
Henry Ford Hospital Medical Journal
No abstract provided.
Genetic Studies Of Multiple Endocrine Neoplasia Type 2 Syndromes: A Workshop Commentary, Nancy E. Simpson
Genetic Studies Of Multiple Endocrine Neoplasia Type 2 Syndromes: A Workshop Commentary, Nancy E. Simpson
Henry Ford Hospital Medical Journal
No abstract provided.
Medical Applications Of Computers In The Hospital, Laurens V. Ackerman, Michael E. Somand
Medical Applications Of Computers In The Hospital, Laurens V. Ackerman, Michael E. Somand
Henry Ford Hospital Medical Journal
No abstract provided.
Computer Applications In The Vascular Registry Of Henry Ford Hospital: Use Of A Simplified Access Method, Joseph P. Elliott Jr., Kunwar Kapoor, John G. Hageman, D. Emerick Szilagyi, Roger F. Smith, Michalene Mcpharlin
Computer Applications In The Vascular Registry Of Henry Ford Hospital: Use Of A Simplified Access Method, Joseph P. Elliott Jr., Kunwar Kapoor, John G. Hageman, D. Emerick Szilagyi, Roger F. Smith, Michalene Mcpharlin
Henry Ford Hospital Medical Journal
The Vascular Registry of Henry Ford Hospital was initiated by one of the authors in 1957 to provide a consistent and accurate method of documenting and correlating the clinical results of the treatment of occlusive and aneurysmal arterial diseases. Data collection for each patient includes demographic information, treatment of clinical problems, and followup observations. Initially, the system consisted of keypunch cards and eventually magnetic tape processing. By 1980, it was necessary to further update the system because of the increase in patient volume, the need to minimize manual manipulations, and the demand for research data. The present system uses institutional …
Development Of A Nephrology And Hypertension Information System, Francis Dumler, Gerard Zasuwa, Nathan W. Levin
Development Of A Nephrology And Hypertension Information System, Francis Dumler, Gerard Zasuwa, Nathan W. Levin
Henry Ford Hospital Medical Journal
This article describes our experience in the development and implementation of a computerized information system specifically designed for a Division of Nephrology and Hypertension. Specific issues related to planning and implementation are discussed, and potential pitfalls in setting up such a system are addressed. The combination of a mainframe and a miniframe as integral parts of the system and the development of peripheral support in specific applications using a personal microcomputer are also described. The important area of user/computer interface and of user motivation is discussed in the light of the experience acquired while implementing the current system.
Automating The Expertise Of The Neuropsychologist, Kenneth M. Adams, Gregory G. Brown
Automating The Expertise Of The Neuropsychologist, Kenneth M. Adams, Gregory G. Brown
Henry Ford Hospital Medical Journal
No abstract provided.
Cooperation Between A Radiology Computer Consortium And A Computer Manufacturer In The Development Of A Radiology Information System, Matthew W. Burke, Laurens V. Ackerman
Cooperation Between A Radiology Computer Consortium And A Computer Manufacturer In The Development Of A Radiology Information System, Matthew W. Burke, Laurens V. Ackerman
Henry Ford Hospital Medical Journal
This article reports on the formation of a Radiology Information System Consortium (RISC) by 13 hospitals and medical centers in the United States, including Henry Ford Hospital in Detroit, and the cooperation between this consortium and a major manufacturer of computers and software. Digital Equipment Corporation (DEC), for the common goal of developing a state-of-the-art radiology information system.
Developing An Integrated Natural Language Database For Gastrointestinal Disease, Peter J. Feczko, Laurens V. Ackerman, Robert D. Halpert, Stuart M. Simms
Developing An Integrated Natural Language Database For Gastrointestinal Disease, Peter J. Feczko, Laurens V. Ackerman, Robert D. Halpert, Stuart M. Simms
Henry Ford Hospital Medical Journal
Using a mainframe computer connected to the Henry Ford Hospital computer network, we developed a database for gastrointestinal disease which includes data from radiologic and endoscopic gastrointestinal examinations, along with corresponding pathologic diagnosis. Because of the large volume of procedures in our practice, we developed several unique features for our system. The user enters data by responding to a series of question-and-answer sets constructed by the clinical staff, who do not have experience in computer programming. Data is stored in a hierarchical format using natural language. Boolean logic is used to retrieve data so that different procedures can be correlated …
Distributed Computing In A Hospital Environment, Steven R. Lund, Laurens V. Ackerman, James B. Martin
Distributed Computing In A Hospital Environment, Steven R. Lund, Laurens V. Ackerman, James B. Martin
Henry Ford Hospital Medical Journal
Obtaining appropriate information in a timely fashion in medical practice has always been a burden for the practitioner. In a large hospital which undertakes major computer projects, this burden is intensified because information is not always available in a form directly usable by the physician or support personnel; it is now accumulated on diverse magnetic media where it is moved and processed as electronic pulses. This paper describes a solution which freely allows continued automation at different rates throughout a large hospital while expediting the movement of information where it is needed in a form understandable by the recipient.
Intracerebral Hemorrhage After Carotid Endarterectomy, José Biller, Andrew C. Hayes, Fred N. Littooy, William H. Baker
Intracerebral Hemorrhage After Carotid Endarterectomy, José Biller, Andrew C. Hayes, Fred N. Littooy, William H. Baker
Henry Ford Hospital Medical Journal
Intracerebral hemorrhage (ICH) is a rare complication of carotid endarterectomy (CE). In our multicenter series of 1,180 CE (Baker-Littooy), three ICH occurred, of which two were fatal. One patient was receiving anticoagulants because ofa prosthetic aortic valve; another had rupture of a known ipsilateral intracranial aneurysm. Both occurred more than six weeks postoperatively. The third patient, who was hypertensive, had a nonfatal ipsilateral thalamic hemorrhage on the third postoperative day. Though these three patients represent only 0.25% of our series, they constitute 12% of our total strokes. ICH constitutes the largest percentage of nontechnically-related strokes and noncardiac deaths after CE.
A Microcomputer Database In A Clinical Environment, Dennis R. Ownby, Thomas A. Burnett
A Microcomputer Database In A Clinical Environment, Dennis R. Ownby, Thomas A. Burnett
Henry Ford Hospital Medical Journal
No abstract provided.