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The Effect Of Selective Hypothermia On Stroke Volume, Thomas K. Mattingly

Electronic Thesis and Dissertation Repository

Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was …