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Open Access. Powered by Scholars. Published by Universities.®

Medical Specialties

University of Tennessee, Knoxville

2011

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Full-Text Articles in Medicine and Health Sciences

Characterization Of A Small Animal Spect Platform For Use In Preclinical Translational Research, Dustin Ryan Osborne Dec 2011

Characterization Of A Small Animal Spect Platform For Use In Preclinical Translational Research, Dustin Ryan Osborne

Doctoral Dissertations

Imaging Iodine-125 requires an increased focus on developing an understanding of how fundamental processes used by imaging systems work to provide quantitative output for the imaging system. Isotopes like I-125 pose specific imaging problems that are a result of low energy emissions as well as how closely spaced those emissions are in the spectrum. This work seeks to characterize the performance of a small animal SPECT-CT imaging system with respect to imaging I-125 for use in a preclinical translational research environment and to understand how the performance of this system relates to critical applications such as attenuation and scatter correction. …

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The Effect Of Midazolam On End-Tidal Concentration Of Isoflurane Necessary To Prevent Movements In Dogs, Reza Seddighi Dvm, Ms, Phd, Dip Acva Apr 2011

The Effect Of Midazolam On End-Tidal Concentration Of Isoflurane Necessary To Prevent Movements In Dogs, Reza Seddighi Dvm, Ms, Phd, Dip Acva

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

Objective To determine the possible additive effect of midazolam, a GABAA agonist, on the end-tidal concentration of isoflurane that prevents movement (MACNM) in response to noxious stimulation. Study design Randomized crossover experimental study. Animals Six, healthy, adult intact male, mixed-breed dogs. Methods After baseline isoflurane MACNM (MACNM-B) determination, midazolam was administered as a low (LDS), medium (MDS) or high (HDS) dose series of midazolam. Each series consisted of two dose levels, low and high. The LDS was a loading dose (Ld) of 0.2 mg kg-1 and CRI (2.5 μg kg-1 minute-1) (LDL), followed by an Ld (0.4 mg kg-1) and …

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