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Microscopic -- chemically induced; Histamine H2 Antagonists -- adverse effects; Proton Pump Inhibitors -- adverse effects
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Full-Text Articles in Medicine and Health Sciences
Comparing The Long Term Use Of H2 Antagonists (H2ras) And Proton Pump Inhibitors (Ppis) And The Incidence Of Colitis, Reiner Kremer
Comparing The Long Term Use Of H2 Antagonists (H2ras) And Proton Pump Inhibitors (Ppis) And The Incidence Of Colitis, Reiner Kremer
Physician Assistant Scholarly Project Posters
• Commonly used medications for GERD may affect the colonic mucosa
• H2 antagonists (H2RAs) ranitidine, cimetidine famotidine reduce acid secretion by 60 to 70%.
• Proton pump inhibitors (PPIs) omeprazole, pantoprazole, lansoprazole, esomeprazole and rabeprazole reduce acid secretion by inhibiting the H+ (proton) secreting pump, reducing hydrochloric acid by 80 to 95%.
• Diarrhea is one of the most commonly reported adverse events.
• H2RAs and PPIs have the physiological and functional potential to interfere with gastrointestinal physiology by altering intestinal pH.
• Microcytic colitis causing chronic diarrhea and colonic inflammation is a significant complication risk after the > 4-8 …