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Full-Text Articles in Medicine and Health Sciences
Structural Atrophy Of The Right Superior Frontal Gyrus In Adolescents With Severe Irritability, Ji-Woo Seok, Sahil Bajaj, Brigette S. Vaughan, Arica Lerdahl, William Garvey, Alexandra Bohn, Ryan Edwards, Christopher J. Kratochvil, James Blair, Soonjo Hwang
Structural Atrophy Of The Right Superior Frontal Gyrus In Adolescents With Severe Irritability, Ji-Woo Seok, Sahil Bajaj, Brigette S. Vaughan, Arica Lerdahl, William Garvey, Alexandra Bohn, Ryan Edwards, Christopher J. Kratochvil, James Blair, Soonjo Hwang
Journal Articles: Psychiatry
Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto-striatal-temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel-based morphometry and surface-based morphometry. …
Neural Responses To Fluoxetine In Youths With Disruptive Behavior And Trauma Exposure: A Pilot Study, Soonjo Hwang, Unsun Chung, Yongmin Chang, Eunji Kim, Ji-Woo Suk, Harma Meffert, Christopher J. Kratochvil, Ellen Leibenluft, James Blair
Neural Responses To Fluoxetine In Youths With Disruptive Behavior And Trauma Exposure: A Pilot Study, Soonjo Hwang, Unsun Chung, Yongmin Chang, Eunji Kim, Ji-Woo Suk, Harma Meffert, Christopher J. Kratochvil, Ellen Leibenluft, James Blair
Journal Articles: Psychiatry
Objective: A preliminary investigation of the impact of a serotonergic agent (fluoxetine) on symptom profile and neural response in youths with disruptive behavior disorders (DBDs) and a history of trauma exposure. Methods: There were three participant groups: (i) Youths with DBDs and trauma exposure who received fluoxetine treatment for 8 weeks (n = 11); (ii) A matched group of youths with DBDs and trauma exposure who received routine regular follow-up in an outpatient clinic (n = 10); and (iii) Typically developing youths (n = 18). All participants conducted an expression processing functional magnetic resonance imaging task twice, …