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Methods Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Methods Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.
Ultra-Small Rnas As Toll-Like Receptor-3 Antagonists, Jayakrishna Ambati
Ultra-Small Rnas As Toll-Like Receptor-3 Antagonists, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Provided are methods and compositions for the treatment or prevention of macular degeneration or other diseases or disorders associated with activation of TLR3. Administration of double stranded RNAs having a length of 22 nucleotides or less treats or prevents macular degeneration or other diseases or disorders associated with activation of TLR3 due to the ability of the RNAs to bind to but not activate TLR3. Furthermore, all double stranded RNAs (both targeted and non-targeted) of 22 nucleotides or less in length can bind to but not activate TLR3 and thereby treat or prevent such conditions. Also provided of a method …