Medicine and Health Sciences Commons^™

Assessing The Effectiveness Of The New Senior Ed Program At Summa Akron City Hospital, Ahmed F. Ozgur

Williams Honors College, Honors Research Projects

Objectives: To compare the outcomes of patients seen during a pilot Senior Emergency Department (ED) program to a historical cohort of geriatric patients receiving usual ED care.

Methods: We performed a retrospective cohort analysis of quality assurance data obtained to evaluate the implementation of a pilot Senior ED program at a 78,000 visit hospital ED. The historical cohort covered 1/23/2012 to 12/31/2012. The pilot Senior ED program was implemented from 1/1/2013 to 12/31/2013. Patients 65 years and older arriving between 8:30 am and 8:30 pm were triaged to a 15 bed Senior ED. Interventions included assessment by a nurse transitional …

Modulation Of Body Weight By Intestinal Flora In Orphan Nuclear Receptor Shp-/- Mice, Ryan Mifflin

Williams Honors College, Honors Research Projects

The whole-body deletion of small heterodimer partner (SHP) in mice is associated with protection from diet-induced obesity and hepatic steatosis upon feeding of a western diet. This protection was reported to be mediated through decreases in hepatic gene expression for lipogenesis, as well as increases in gene expression for fatty acid oxidation. SHP has been known to regulate the expression of the CYP7A1 gene, encoding the rate-limiting enzyme for bile acid synthesis, thereby altering the bile acid pool. The effects of this altered bile acid profile on the gut microbiome are unknown, as some bacteria in the gut are responsible …