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Full-Text Articles in Medicine and Health Sciences
A Role For Adipocytes And Adipose Stem Cells In The Breast Tumor Microenvironment And Regenerative Medicine, Courtney K. Brock, Katherine L. Hebert, Maria Artiles, Maryl K. Wright, Thomas Cheng, Gabrielle O. Windsor, Khoa Nguyen, Madlin S. Alzoubi, Bridgette M. Collins-Burow, Elizabeth C. Martin, Frank H. Lau, Bruce A. Bunnell, Matthew E. Burow
A Role For Adipocytes And Adipose Stem Cells In The Breast Tumor Microenvironment And Regenerative Medicine, Courtney K. Brock, Katherine L. Hebert, Maria Artiles, Maryl K. Wright, Thomas Cheng, Gabrielle O. Windsor, Khoa Nguyen, Madlin S. Alzoubi, Bridgette M. Collins-Burow, Elizabeth C. Martin, Frank H. Lau, Bruce A. Bunnell, Matthew E. Burow
School of Medicine Faculty Publications
Obesity rates are climbing, representing a confounding and contributing factor to many disease states, including cancer. With respect to breast cancer, obesity plays a prominent role in the etiology of this disease, with certain subtypes such as triple-negative breast cancer having a strong correlation between obesity and poor outcomes. Therefore, it is critical to examine the obesity-related alterations to the normal stroma and the tumor microenvironment (TME). Adipocytes and adipose stem cells (ASCs) are major components of breast tissue stroma that have essential functions in both physiological and pathological states, including energy storage and metabolic homeostasis, physical support of breast …
Precision Medicine And Triple-Negative Breast Cancer: Current Landscape And Future Directions, Fokhrul Hossain, Samarpan Majumder, Justin David, Lucio Miele
Precision Medicine And Triple-Negative Breast Cancer: Current Landscape And Future Directions, Fokhrul Hossain, Samarpan Majumder, Justin David, Lucio Miele
School of Medicine Faculty Publications
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer associated with a high recurrence and metastasis rate that affects African-American women disproportionately. The recent approval of targeted therapies for small subgroups of TNBC patients by the US ‘Food and Drug Administration’ is a promising development. The advancement of next-generation sequencing, particularly somatic exome panels, has raised hopes for more individualized treatment plans. However, the use of precision medicine for TNBC is a work in progress. This review will discuss the potential benefits and challenges of precision medicine for TNBC. A recent clinical trial designed to target …