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Full-Text Articles in Medicine and Health Sciences
Hippo Signaling Pathway: A Comprehensive Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Mahsa Rostamian Delavar, Fatemeh Piroozian, Masoud Baghi, Khoa Nguyen, Thomas Cheng, Cecilia Vittori, David Worthylake, Suresh K. Alahari
Hippo Signaling Pathway: A Comprehensive Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Mahsa Rostamian Delavar, Fatemeh Piroozian, Masoud Baghi, Khoa Nguyen, Thomas Cheng, Cecilia Vittori, David Worthylake, Suresh K. Alahari
School of Medicine Faculty Publications
Breast cancer (BC) is the most frequently diagnosed malignancy in women and a major public health concern. The Hippo pathway is an evolutionarily conserved signaling pathway that serves as a key regulator for a wide variety of biological processes. Hippo signaling has been shown to have both oncogenic and tumor-suppressive functions in various cancers. Core components of the Hippo pathway consist of various kinases and downstream effectors such as YAP/TAZ. In the current report, differential expression of Hippo pathway elements as well as the correlation of Hippo pathway mRNAs with various clinicopathologic characteristics, including molecular subtypes, receptor status, and methylation …
Nr4a Family Genes: A Review Of Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Jordyn Fong, Suresh K. Alahari
Nr4a Family Genes: A Review Of Comprehensive Prognostic And Gene Expression Profile Analysis In Breast Cancer, Hassan Yousefi, Jordyn Fong, Suresh K. Alahari
School of Medicine Faculty Publications
This report analyzes nuclear receptor (NR) subfamily 4A’s potential role in treating those diagnosed with breast cancer. Here we reviewed the current literature on NR4 family members. We also examined the relative gene expression of the NR4A receptor subfamily in the basal, HER2 (human epidermal growth factor receptor 2) positive, luminal A, and luminal B subtypes using data from tumor samples in The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC). These data showed a positive link between NR4A1-NR4A3 expression and increased overall survival and relapse-free survival in breast cancer patients. In addition, we observed …