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Full-Text Articles in Medicine and Health Sciences
Altering Gene Expression Using Antisense Oligonucleotide Therapy For Hearing Loss, Katelyn N. Robillard, Erik De Vrieze, Erwin Van Wijk, Jennifer J. Lentz
Altering Gene Expression Using Antisense Oligonucleotide Therapy For Hearing Loss, Katelyn N. Robillard, Erik De Vrieze, Erwin Van Wijk, Jennifer J. Lentz
School of Medicine Faculty Publications
Hearing loss affects more than 430 million people, worldwide, and is the third most common chronic physical condition in the United States and Europe (GBD Hearing Loss Collaborators, 2021; NIOSH, 2021; WHO, 2021). The loss of hearing significantly impacts motor and cognitive development, communication, education, employment, and overall quality of life. The inner ear houses the sensory organs for both hearing and balance and provides an accessible target for therapeutic delivery. Antisense oligonucleotides (ASOs) use various mechanisms to manipulate gene expression and can be tailor-made to treat disorders with defined genetic targets. In this review, we discuss the preclinical advancements …
Conversations In Cochlear Implantation: The Inner Ear Therapy Of Today, Grant Rauterkus, Anne K. Maxwell, Jacob B. Kahane, Jennifer J. Lentz, Moises A. Arriaga
Conversations In Cochlear Implantation: The Inner Ear Therapy Of Today, Grant Rauterkus, Anne K. Maxwell, Jacob B. Kahane, Jennifer J. Lentz, Moises A. Arriaga
School of Medicine Faculty Publications
As biomolecular approaches for hearing restoration in profound sensorineural hearing loss evolve, they will be applied in conjunction with or instead of cochlear implants. An understanding of the current state-of-the-art of this technology, including its advantages, disadvantages, and its potential for delivering and interacting with biomolecular hearing restoration approaches, is helpful for designing modern hearing-restoration strategies. Cochlear implants (CI) have evolved over the last four decades to restore hearing more effectively, in more people, with diverse indications. This evolution has been driven by advances in technology, surgery, and healthcare delivery. Here, we offer a practical treatise on the state of …