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Full-Text Articles in Medicine and Health Sciences
Nf-Kb (P50/P65)-Mediated Pro-Inflammatory Microrna (Mirna) Signaling In Alzheimer's Disease (Ad), Walter J. Lukiw
Nf-Kb (P50/P65)-Mediated Pro-Inflammatory Microrna (Mirna) Signaling In Alzheimer's Disease (Ad), Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.
Downregulation Of Neurofilament Light Chain Expression In Human Neuronal-Glial Cell Co-Cultures By A Microbiome-Derived Lipopolysaccharide-Induced Mirna-30b-5p, Aileen I. Pogue, Vivian R. Jaber, Nathan M. Sharfman, Yuhai Zhao, Walter J. Lukiw
Downregulation Of Neurofilament Light Chain Expression In Human Neuronal-Glial Cell Co-Cultures By A Microbiome-Derived Lipopolysaccharide-Induced Mirna-30b-5p, Aileen I. Pogue, Vivian R. Jaber, Nathan M. Sharfman, Yuhai Zhao, Walter J. Lukiw
School of Medicine Faculty Publications
Microbiome-derived Gram-negative bacterial lipopolysaccharide (LPS) has been shown by multiple laboratories to reside within Alzheimer's disease (AD)-affected neocortical and hippocampal neurons. LPS and other pro-inflammatory stressors strongly induce a defined set of NF-kB (p50/p65)-sensitive human microRNAs, including a brain-enriched Homo sapien microRNA-30b-5p (hsa-miRNA-30b-5p; miRNA-30b). Here we provide evidence that this neuropathology-associated miRNA, known to be upregulated in AD brain and LPS-stressed human neuronal-glial (HNG) cells in primary culture targets the neurofilament light (NF-L) chain mRNA 3'-untranslated region (3'-UTR), which is conducive to the post-transcriptional downregulation of NF-L expression observed within both AD and LPS-treated HNG cells. A deficiency of NF-L …
Fission Impossible: Stabilized Mirna-Based Analogs In Neurodegenerative Disease, Walter J. Lukiw
Fission Impossible: Stabilized Mirna-Based Analogs In Neurodegenerative Disease, Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.
New Inroads Into Our Understanding Of The Tauopathies, Alzheimer's Disease, And The Contribution Of Altered Protein Conformation To Human Neurological Disease, Walter J. Lukiw
School of Medicine Faculty Publications
No abstract provided.