Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Synergistic Interactions Of Chlorambucil, Dha, And Trail In Jurkat And H460 Human Cancer Cells, Jennifer Ellen Bush-O'Donnell
Synergistic Interactions Of Chlorambucil, Dha, And Trail In Jurkat And H460 Human Cancer Cells, Jennifer Ellen Bush-O'Donnell
Theses, Dissertations and Capstones
Traditional chemotherapeutic drugs are prone to toxicity and may result in secondary cancers. In recent years much attention has been garnered by alternate methods of cancer treatment with fewer side effects, including immunotherapy and administration of ω-3 fatty acids, both of which have been shown to cause apoptosis in cancer cells. Docosahexaenoic acid (DHA), a fatty acid, is a normal component of cell membranes and is safe for systemic administration. The cytokine TRAIL (tumor necrosis factorrelated apoptosis-inducing ligand) is able to induce apoptosis in cancer cells while sparing normal tissue. In this study, the alkylating agent chlorambucil (CLB) was combined …
Utilization Of Emergency Policies And Procedures By Division I-A And Division I-Aa Intercollegiate Athletic Programs, Brandy A. Petty
Utilization Of Emergency Policies And Procedures By Division I-A And Division I-Aa Intercollegiate Athletic Programs, Brandy A. Petty
Theses, Dissertations and Capstones
The need for an established emergency policy and procedures plan in the college and university setting has been confirmed by various organizations such as: National Safety Council (NSC), Federal Emergency Management Agency (FEMA), National Emergency Management Association (NEMA), National Athletic Trainers’ Association (NATA), National Collegiate Athletic Association (NCAA), and the American College of Sports Medicine (ACSM). The duty of these emergency policies and procedures is twofold. The first is to provide immediate care to student-athletes in an emergency situation. The second purpose is to avoid liability issues that may arise following an emergency situation. The premise behind the establishment and …
The Role Of Ap-1 Transcription Complex In Retinoic Acid-Dependent B16 Melanoma Cell Growth Arrest And Differentiation, Ying Huang
Theses, Dissertations and Capstones
Our laboratory has been studying the effects of all-trans retinoic acid (atRA) on the growth and differentiation of the B16 mouse melanoma cells. RA inhibits both anchorage-dependent and –independent growth and stimulates melanin production in B16 cells, which are accompanied by an increase in AP-1 activity. To further investigate the RA-induced AP-1 activity, I established clones of B16 stably expressing an AP-1-luciferase reporter gene. Treatment of these clones with phorbol dibutyrate (PDB), a known activator of AP-1, rapidly increased AP-1 activity which reached its maximum level at 2-4 h and returned to baseline level by 24 h. In contrast, RA …