Medicine and Health Sciences Commons^™

A Review Of Monoclonal Antibody Regimens In Small Cell Lung Cancer Compared To Chemotherapy Standard Of Care, Rachael St. Clair

Theses and Graduate Projects

Background: Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor closely linked to tobacco use. Chemotherapy with platinum-etoposide is the current standard of care, with positive initial response rates and subsequently high rates of recurrence and death. Monoclonal antibodies are a therapeutic drug class attempting to block suppression of T cell activation, enabling a stronger immune response.

Purpose: The current predicament in SCLC treatment is determining if monoclonal antibodies have any effect on overall survival. Chemotherapy briefly suppresses SCLC, but given its rapid progression and recurrence, it is necessary to investigate alternative treatments. The following literature review …

Immunotherapy Versus Chemotherapy: Which Treatment Offers Better Survival To Adults With Advanced Melanoma?, Nadeline Abro

Theses and Graduate Projects

Background: Melanoma is the most serious type of skin cancer that can lead to metastasis. The main treatment for melanoma is surgical removal — a wide excision. Patients with advanced melanoma require further treatment such as chemotherapy or immunotherapy due to the concern of continuous spread.

Purpose: Literature review of studies to examine if patients with advanced melanoma, treated with immunotherapy, enjoy better overall survival rates than patients treated with chemotherapy?

Methods: A comprehensive literature review was conducted using using the search terms <(advanced melanoma) AND (immunotherapy)) AND (chemotherapy)) AND (skin cancer)>. Inclusion criteria were studies that were related to immunotherapy and chemotherapy among advanced melanoma patients. Exclusion …