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Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams Sep 2011

Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams

Russ Chess-Williams

Objective: The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of bladder dysfunction. The present study investigates neurokinin receptor-mediated contractility of detrusor muscle in the idiopathic overactive and neurogenic overactive bladder and investigates the neurokinin receptor subtypes involved.

Methods: Human bladder was obtained from patients undergoing cystectomy (normal) or clam cystoplasty (idiopathic overactive) and from patients with spinal injuries (neurogenic overactive). Strips of isolated detrusor muscle were mounted in …


Anomalia Anorretal: Relato De Caso Clínico / Anorectal Malformations: A Case Report, Everton Fernando Alves, Jucélia Lins Dos Santos Oliveira, Maria Do Rosário Martins Mar 2006

Anomalia Anorretal: Relato De Caso Clínico / Anorectal Malformations: A Case Report, Everton Fernando Alves, Jucélia Lins Dos Santos Oliveira, Maria Do Rosário Martins

Everton Fernando Alves

A Anomalia Anorretal é uma importante causa de obstrução gastrintestinal, com alta taxa de morbi-mortalidade em recém-natos. Há diversos mecanismos patológicos possíveis para explicar esta malformação e duas explicações clássicas de sua gênese são um defeito de recanalização do tubo intestinalou uma interrupção no suprimento sanguíneo durante a vida intra-uterina, entretanto a causa ainda é desconhecida. Desta forma, o presenteestudo tem por objetivo descrever um caso clínico de uma criança internada em um Hospital do Município de Maringá-PR, portadora de uma anomalia anorretal (Ânus imper-furado). Para este estudo, foram coletados dados do prontuário da criança, exame físico e uma entrevista …


New Trends In Shock Resuscitation, Christopher Michetti Feb 2006

New Trends In Shock Resuscitation, Christopher Michetti

Christopher P. Michetti, M.D., F.A.C.S.

No abstract provided.


Contemporary Analysis Of Thoracic Aortic Injury: Importance Of Screening Based On Crash Characteristics, Christopher Michetti, R Hanna, J Crandall, S Fakhry Dec 2005

Contemporary Analysis Of Thoracic Aortic Injury: Importance Of Screening Based On Crash Characteristics, Christopher Michetti, R Hanna, J Crandall, S Fakhry

Christopher P. Michetti, M.D., F.A.C.S.

No abstract provided.


Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams Dec 2005

Depressed Contractile Responses To Neurokinin A In Idiopathic But Not Neurogenic Overactive Human Detrusor Muscle, Donna Sellers, Christopher Chapple, Douglas Hay, Russell Chess-Williams

Donna Sellers

Objective: The role of tachykinins such as neurokinin A in regulating bladder function is unclear, but NK2 receptors seem to mediate contraction in the human bladder and it has been suggested that these peptides may have a role in the pathophysiology of bladder dysfunction. The present study investigates neurokinin receptor-mediated contractility of detrusor muscle in the idiopathic overactive and neurogenic overactive bladder and investigates the neurokinin receptor subtypes involved.

Methods: Human bladder was obtained from patients undergoing cystectomy (normal) or clam cystoplasty (idiopathic overactive) and from patients with spinal injuries (neurogenic overactive). Strips of isolated detrusor muscle were mounted in …


“You’Re Awfully Old To Have This Disease”: Experiences Of Stigma And Ageism In Adults 50 Years An Older Living With Hiv/Aids., Charles A. Emlet Dec 2005

“You’Re Awfully Old To Have This Disease”: Experiences Of Stigma And Ageism In Adults 50 Years An Older Living With Hiv/Aids., Charles A. Emlet

Charles Emlet

No abstract provided.