Medicine and Health Sciences Commons^™

Efficacy Of A Novel Mitochondrial-Derived Peptide In A Porcine Model Of Myocardial Ischemia/Reperfusion Injury, Thomas E. Sharp, Zhenwei Gong, Amy Scarborough, Eric S. Goetzman, Murtuza J. Ali, Pablo Spaletra, David J. Lefer, Radhika H. Muzumdar, Traci T. Goodchild

School of Medicine Faculty Publications

With the complexities that surround myocardial ischemia/reperfusion (MI/R) injury, therapies adjunctive to reperfusion that elicit beneficial pleiotropic effects and do not overlap with standard of care are necessary. This study found that the mitochondrial-derived peptide S14G-humanin (HNG) (2 mg/kg), an analogue of humanin, reduced infarct size in a large animal model of MI/R. However, when ischemic time was increased, the infarct-sparing effects were abolished with the same dose of HNG. Thus, although the 60-min MI/R study showed that HNG cardioprotection translates beyond small animal models, further studies are needed to optimize HNG therapy for longer, more patient-relevant periods of cardiac …

The Effects Of An Inflammasome Inhibitor Olt1177 On The Development Of Ischemic Heart Failure, Joseph S. Aliaga

Theses and Dissertations

Thesis Abstract

THE EFFECTS OF AN INFLAMMASOME INHIBITOR OLT1177 ON THE DEVELOPMENT OF ISCHEMIC HEART FAILURE

By Joseph S. Aliaga, BS

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University.

Virginia Commonwealth University, 2020

Background: Evidence suggests that prolonged and enhanced pro-inflammatory signaling, modulated by the NLRP3 inflammasome, plays a crucial role in the pathophysiology of several different types of cardiovascular diseases such as acute myocardial infarction (AMI), adverse ventricular remodeling, and heart failure (HF). Consequently, we hypothesize that attenuating the enhanced inflammatory response using a pharmacological NLRP3 …

Sighting Acute Myocardial Infarction Through Platelet Gene Expression., Giuliana Gobbi, Cecilia Carubbi, Guidantonio Malagoli Tagliazucchi, Elena Masselli, Prisco Mirandola, Filippo Pigazzani, Antonio Crocamo, Maria Francesca Notarangelo, Sergio Suma, Elvezia Paraboschi, Giuseppe Maglietta, Srikanth Nagalla, Giulia Pozzi, Daniela Galli, Mauro Vaccarezza, Paolo Fortina, Sankar Addya, Adam Ertel, Paul Bray, Stefano Duga, Carlo Berzuini, Marco Vitale, Diego Ardissino

Department of Cancer Biology Faculty Papers

Acute myocardial infarction is primarily due to coronary atherosclerotic plaque rupture and subsequent thrombus formation. Platelets play a key role in the genesis and progression of both atherosclerosis and thrombosis. Since platelets are anuclear cells that inherit their mRNA from megakaryocyte precursors and maintain it unchanged during their life span, gene expression profiling at the time of an acute myocardial infarction provides information concerning the platelet gene expression preceding the coronary event. In ST-segment elevation myocardial infarction (STEMI), a gene-by-gene analysis of the platelet gene expression identified five differentially expressed genes: FKBP5, S100P, SAMSN1, CLEC4E and S100A12. The logistic regression …

The Relationship Between Plasma Homocysteine And Early Coronary Collateral Vessel Development After Acute Myocardial Infarction, Telat Keleş, Tahi̇r Durmaz, Ni̇hal Akar Bayram, Murat Akçay, Ekrem Yeter, Hüseyi̇n Ayhan, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Aim: Homocysteine is known to inhibit endothelial cell proliferation, which is a key event in angiogenesis. Factors responsible for the presence or absence of coronary collateral circulation are poorly understood. Therefore, in this study we investigated the effect of plasma homocysteine level on the early formation of angiographically visible collaterals after acute myocardial infarction. Materials and Methods: The study included 60 patients that had ST-segment elevation myocardial infarction (STEMI). All the patients underwent coronary angiography 1-4 days after admission (mean: 2.3 ± 1.2 days). Patients were graded according to Rentrop classification. Patients with grade 0 or 1 collateral vessels were …

The Role Of Heart-Type Fatty Acid-Binding Protein (H-Fabp) In Acute Myocardial Infarction (Ami) Compared To Conventional Cardiac Biochemical Markers, Hati̇ce Paşaoğlu, Ebru Ofluoğlu, Mustafa İlhan, Ati̇ye Çengel, Murat Özdemi̇r, Emre Durakoğlugi̇l, Murat Erden

Turkish Journal of Medical Sciences

Aim: To investigate the clinical implications of serum heart-type fatty acid-binding protein (H-FABP) compared to myoglobin, cardiac troponin I (cTnI), and creatine kinase MB isoenzyme (CK-MB) in patients with early phase acute myocardial infarction (AMI). Material and Methods: Patients were grouped clinically according to the American College of Cardiology/European Society of Cardiology new definition of myocardial infarction (MI) and by clinician diagnosis of MI. Serum concentrations of H-FABP, myoglobin, cTnI, and CK-MB were determined in 21 patients with AMI and 44 non-AMI patients. From each patient 3 blood samples were obtained 1-2, 3, and 6 h after the onset chest …

The Effects Of Ticlopidine In Acute Myocardial Infarction As An Adjunctive Treatment To Aspirin In An Intermediate Term Setting, V. Gökhan Ci̇n, Ahmet Temi̇zhan, Hasan Pekdemi̇r, Mehmet Tokaç, Okan Tartanoğlu

Turkish Journal of Medical Sciences

Antiplatelet therapy reduces the risk of subsequent ischemic events in patients suffering from acute myocardial infarction (AMI). In this respect, the multi-agent therapy to be used along with aspirin remains to be determined. In this study, ticlopidine was tried in AMI for its potential additive effects over aspirin. Ninety patients with similar clinical characteristics were involved and were followed up for 3 and 6 months. All patients were assigned to receive ticlopidine plus aspirin or aspirin alone. Major cardiac events such as death and reinfarction were primary end-points whereas the need for revascularization was the secondary end-point at 3 and …

Cardiac Troponin T In Diagnosis Of Acute Myocardial Infarction, Gülinnaz Alper, Ömür Erkizan, Can Hasdemi̇r, Azem Akilli, Taner Onat

Turkish Journal of Medical Sciences

Cardiac Troponin T (TnT) is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. This study was designed to evaluate the diagnostic efficiency of TnT enzyme immunoassay for the early diagnosis of AMI (Acute Myocardial Infarction) and to compare this newly developed test with the conventionally used cardiac enzyme tests in need of an alternative test of greater sensitivity and specificity. The study population consisted of 13 patients with a mean age of 52±8 years who were hospitalized for AMI. Blood …

Blood Lactate/Pyruvate As A Predictor Of Shockdevelopment In Acute Myocardial Infarction, Arzu Seven, Sabiha Ci̇velek, Figen Kocaman, Lale Koldaş, Gülden Candan

Turkish Journal of Medical Sciences

This study, designed to investigate the blood lactate and pyruvate levels in AMI, was carried out on 41 patients. Based upon the localization of AMI, the patients were studied under anterior AMI (n=17), anteroseptal AMI (n=9) and inferior AMI (n=15) groups. Left ventricular failure developed in five patients with anterior AMI and in one patient with anteroseptal AMI. Cardiogenic shock developed in two patients with anterior AMI. Lactate and pyruvate were analysed in the blood samples drawn 24-48 hours after AMI. CPK, CPK-MB, AST and LDH activities were determined in the sera of blood samples drawn within 6-24 hours of …