Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able
LSU Doctoral Dissertations
Obesity is a metabolic disorder characterized by excess energy storage in adipose tissue and it increases the risk for Type 2 diabetes. Impaired or altered adipocyte function during obesity can contribute to metabolic dysfunction. DBC1 (deleted in breast cancer 1) and EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2) have been shown to have a role in fat cell development and function. DBC1 is typically localized in the nucleus and can regulate a variety of epigenetic modifiers, transcription factors, and nuclear receptors. EHMTs 1 and 2, also known respectively as GLP and G9a, were initially classified as …
The Role Of Pannexin 1 During Human Adipogenesis In Vitro, Jamie Emily Ching
The Role Of Pannexin 1 During Human Adipogenesis In Vitro, Jamie Emily Ching
Electronic Thesis and Dissertation Repository
Obesity is the unhealthy accumulation of adipose tissue and affects 10% of the global population. A study reported the loss of mouse pannexin 1 (Panx1), a large channel forming protein, increased adipogenesis in murine adipose derived stem cells (ASCs). Our study was designed to determine if human pannexin 1 (PANX1) inhibits adipogenesis in vitro using human ASCs and induced-mesenchymal stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs). Pharmacological inhibition of PANX1 using carbenoxolone halted adipogenesis in both the ASCs and iMSCs. When PANX1 was inhibited by probenecid, adipogenesis was impeded in iMSCs, but not in ASCs. PANX1-ablated iPSCs …