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Full-Text Articles in Medicine and Health Sciences
The Ketogenic Diet: A Noteworthy Treatment For Pediatric Patients With Refractory Epilepsy, Hannah Christian
The Ketogenic Diet: A Noteworthy Treatment For Pediatric Patients With Refractory Epilepsy, Hannah Christian
Honors Theses
Although epilepsy has been a well-documented neurological disorder for thousands of years, a third of individuals with epilepsy today still have seizures that are not well managed. After the addition of benzodiazepines to other anticonvulsants in the 1950s, doctors have largely focused on treating epilepsy with medications. But, an older treatment has been recently reintroduced into the medical community to help remediate seizure activity. Interestingly, a high fat and low carbohydrate diet regimen called the ketogenic diet has proven to be helpful to some people with refractory epilepsy, that is, epilepsy that does not respond well to medications. In a …
Mutations In The Human Follicle Stimulating Hormone Receptor Caveolin Interaction Motif Cause Increased Basal Activation, Elizabeth Altman
Mutations In The Human Follicle Stimulating Hormone Receptor Caveolin Interaction Motif Cause Increased Basal Activation, Elizabeth Altman
Honors Theses
Over twelve percent of women aged fifteen to forty-five in America suffer from infertility and/or impaired fecundity and over seven million women have used infertility services, such as intrauterine insemination and in vitro fertilization. Some cases of infertility may be due to dysfunctional human follicle stimulating hormone (hFSH) signaling. hFSH plays a role in spermatogenesis in males, as well as follicle maturation and estrogen production in females. Problems with either hFSH or the hFSH receptor (hFSHR) decrease fertility in males and cause complete infertility in females. As part of the hypothalamic-pituitary-gonadal axis, hFSH is released from the pituitary gland and …
Hiv-1 Integrase Multimerization By Quinoline Based Drugs, Samer Beauti
Hiv-1 Integrase Multimerization By Quinoline Based Drugs, Samer Beauti
Honors Theses
Human Immunodeficiency Virus Type 1 (HIV-1), a single stranded RNA retrovirus, affects over 30,000,000 people world-wide1. The virus works by infecting and promoting destruction of CD4 immune cells. and thus, suppressing proper immune functions2. Contrary to DNA viruses, the absence of extensive proofreading mechanisms in RNA viruses makes HIV latency a major obstacle in the discovery of long-term, effective treatments. Moreover, the importance of exploring novel therapeutic targets and designing complimentary inhibitory molecules remains steadfast in HIV research3 Recently, HIV-1 Integrase (IN) multimerization, the core enzyme used for integration of the viral DNA into an invaded host chromosome, has been …