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Full-Text Articles in Medicine and Health Sciences
Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley
Leucine Supplementation In Cuprizone-Induced Oligodendrocyte Toxicity, Michael Ley
Williams Honors College, Honors Research Projects
Cuprizone is a copper chelator that induces demyelination in the central nervous system when fed to mice. This compound is thought to target Complex IV and disrupt mitochondrial metabolism leading to loss of myelin-producing oligodendrocytes. In this proposal, we further examine the chemical and toxicological properties of cuprizone. Immunofluorescence imaging and microarray data on MO3.13 cells treated with cuprizone revealed the possibility of alterations in lysosomal function, as well as mitochondrial disruption via mTOR and Electron Transport Chain (ETC) related pathways. Cell viability assays conducted suggest that addition of Branched-Chain Amino Acids, most commonly used from literature, leucine, can increase …
Kangaroo Mother Care And Traditional Care, Arianna Smola, Kirsten Lawson
Kangaroo Mother Care And Traditional Care, Arianna Smola, Kirsten Lawson
Williams Honors College, Honors Research Projects
Prematurity and low birth weight are leading causes of infant death. Throughout recent years care methods for this population have evolved from incubator care to Kangaroo Mother Care (KMC). The purpose of this systematic review was to answer the following PICO question: in the case of preterm and low birth weight (LBW) infants, how does the technique of Kangaroo Mother Care (KMC) compare to traditional incubator use, regarding long and short-term outcomes of preterm and LBW infant recovery. Methods of this study included the selection of twenty peer-reviewed articles that studied the effect of incubators and KMC on premature and …