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Full-Text Articles in Medicine and Health Sciences
Updates On Epigenetic Alterations To Brca1: Chemosensitivities, Haley Blum
Updates On Epigenetic Alterations To Brca1: Chemosensitivities, Haley Blum
UNO Student Research and Creative Activity Fair
Breast cancer 1, early onset (BRCA1) is a human tumor suppressor gene encoding the BRCA1 protein that maintains genomic integrity. Molecular events may contribute to the loss of BRCA1 function, contributing to site specific tumorigenesis. Loss of BRCA1 function may arise from mutation or epigenetic events. Germline mutations of BRCA1 have been thoroughly implicated in heritable breast and ovarian cancers. More recently, sporadic breast cancer has been shown to be driven by epigenetic alterations to the BRCA1 promoter region, specifically methylation. Breast carcinomas that present with BRCA1 promoter methylation have been associated with triple negative breast cancers, as well …
The Effect Of Arm Swing On Countermovement Vertical Jump Performance, Arash Mohammadzadeh Gonabadi
The Effect Of Arm Swing On Countermovement Vertical Jump Performance, Arash Mohammadzadeh Gonabadi
UNO Student Research and Creative Activity Fair
Vertical jumping is one of the popular ways to evaluate ankle-knee efficiency in athletic population. Arm swing can play a crucial role in enhancing vertical jump performance. This study aimed to address the differences in kinetic and kinematic parameters during countermovement jump motion with arm swing (AS) and no arm swing (NAS). We used OpenSim to examine the efficacy of AS in reducing the impulse applied to the body and changes in range of lower limb joint angles at landing instant. We calculated the maximum vertical peak of the ground reaction force and impulse generated at landing in two different …
Estimating Variations In Metabolic Cost Within The Stride Cycle During Level And Uphill Walking, Arash Mohammadzadeh Gonabadi
Estimating Variations In Metabolic Cost Within The Stride Cycle During Level And Uphill Walking, Arash Mohammadzadeh Gonabadi
UNO Student Research and Creative Activity Fair
Indirect calorimetry provides the average cost of a stride cycle and prevents from identifying which part of the gait cycle causes increased metabolic cost in patients, however, recent simulation methods allow estimating the time profile of metabolic cost within the stride cycle. In this study, we compare the estimations of the time profile of the metabolic cost of two simulation methods for level and uphill walking. We used kinematic, kinetic and electromyography data from level and uphill walking (one participant) to estimate the time profiles of metabolic cost using the muscle-level metabolic model of Umberger using electromyography and kinematic data …
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
An Investigation Of Stimulants: Reviewing Their Effects On The Brain, Including Memory And Microglia, Michael Douchey
UNO Student Research and Creative Activity Fair
Stimulants are a class of drugs that have a variety of effects on the brain, including changes in receptor activity in the brain areas responsible for- memory, attention, emotion, motor control, and the reward pathway. Stimulants may be generally classified by their availability. For example, prescription stimulants, which include drugs such as methylphenidate (Concerta™, Ritalin™) and mixed amphetamine salts (Adderall™), must be prescribed by medical professionals. Another regulated stimulant, albeit one available without a prescription, is nicotine; a highly addictive chemical that is age-restricted by the U.S. federal government. Nicotine is found in tobacco products, and in tobacco-free alternatives including …
The Energy Paradox Of The Ankle-Foot Complex During Human Walking, Nikolaos Papachatzis, Kota Takahashi
The Energy Paradox Of The Ankle-Foot Complex During Human Walking, Nikolaos Papachatzis, Kota Takahashi
UNO Student Research and Creative Activity Fair
Flexor hallucis longus (FHL) is a multiarticular muscle that possesses the potential to alter foot’s functional and mechanical behavior, since it performs multiple significant functions during walking (e.g supports the medial longitudinal arch of the foot).The purpose of this study was to determine if the functional changes of the FHL are associated with the foot’s adaptations to the mechanical demands of walking. Backward walking is an experimental method capable of altering how the forces propagate underneath the foot and disrupting the mechanical function of the FHL muscle. We hypothesized that: (1) the muscle activity of the FHL will increase during …