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Proteomic Analysis Delineates The Signaling Networks Of Plasmodium Falciparum, Brittany Pease
Proteomic Analysis Delineates The Signaling Networks Of Plasmodium Falciparum, Brittany Pease
Electronic Theses and Dissertations
Malaria is a life-threatening disease caused by Plasmodium parasites that are spread through the bites of infected mosquito vectors. It is a worldwide pandemic that threatens 3.4 billion people annually. Currently, there are only a few validated Plasmodium drug targets, while drug resistance continues to rise. This marks the urgency for the development of novel parasite-specific therapeutics. Plasmodium falciparum diverges from the paradigm of the eukaryotic cell cycle by undergoing multiple rounds of DNA replication and nuclear division without cytokinesis. A better understanding of the molecular switches that coordinate the progression of the parasite through the intraerythrocytic developmental stages will …