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Articles 1 - 20 of 20
Full-Text Articles in Medicine and Health Sciences
Ceramic Scaffolds Produced By Computer-Assisted 3d Printing And Sintering: Characterization And Biocompatibility Investigations, Patrick Warnke, Hermann Seitz, Stephan Becker, Sureshan Sivananthan, Eugene Sherry, Qin Liu, Jorge Wiltfang, Timothy Douglas
Ceramic Scaffolds Produced By Computer-Assisted 3d Printing And Sintering: Characterization And Biocompatibility Investigations, Patrick Warnke, Hermann Seitz, Stephan Becker, Sureshan Sivananthan, Eugene Sherry, Qin Liu, Jorge Wiltfang, Timothy Douglas
Qin Liu
Hydroxyapatite (HAP) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. However, in general HAP and TCP scaffolds are not tailored to the exact dimensions of the defect site and are mainly used as granules or beads. Some scaffolds are available as ordinary blocks, but cannot be customized for individual perfect fit. Using computer-assisted 3D printing, an emerging rapid prototyping technique, individual three-dimensional ceramic scaffolds can be built up from TCP or HAP powder layer by layer with subsequent sintering. These scaffolds have precise dimensions and highly defined and regular internal characteristics such as pore size. …
The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke
The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke
Qin Liu
The impaired temporomandibular joint might be the first to benefit from applied tissue engineering techniques because it is small and tissue growth in larger amounts is challenging. Bone and cartilage require different competing environmental conditions to be cultivated in vitro. But coupling both the osteogenic and cartilaginous pathways of mesenchymal stem cell differentiation in homeostasis will be a key essential to grow osteochondral constructs or even the first biological joint replacement in the future.
The aim of this study was to test a single source biomaterial and a single source cell type to engineer a biphasic osteochondral construct in vitro …
Novel Ceramic Bone Replacement Material Ceraball® Seeded With Human Mesenchymal Stem Cells, Timothy Douglas, Qin Liu, Andreas Humpe, Jörg Wiltfang, Sureshan Sivananthan, Patrick Warnke
Novel Ceramic Bone Replacement Material Ceraball® Seeded With Human Mesenchymal Stem Cells, Timothy Douglas, Qin Liu, Andreas Humpe, Jörg Wiltfang, Sureshan Sivananthan, Patrick Warnke
Qin Liu
Objectives: Hydroxyapatite (HA) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. A recently developed material for bone replacement is CeraBall®, which is a mixed HA-TCP scaffold available as porous spherical scaffolds of diameter 4 and 6 mm. Before their use as bone replacement materials in vivo, in vitro testing of these scaffolds is necessary. The goal of this study was to characterise 4 and 6 mm CeraBall® scaffolds in vitro with a view to their future use as bone replacement materials. Materials and methods: The proliferation of human mesenchymal stromal cells (hMSCs) seeded on CeraBall® …
Primordium Of An Artificial Bruch's Membrane Made Of Nanofibers For Engineering Of Retinal Pigment Epithelium Cell Monolayers, Patrick Warnke, Mohammad Alamein, Stuart Skabo, Sebastien Stephens, Robert Bourke, Peter Heiner, Qin Liu
Primordium Of An Artificial Bruch's Membrane Made Of Nanofibers For Engineering Of Retinal Pigment Epithelium Cell Monolayers, Patrick Warnke, Mohammad Alamein, Stuart Skabo, Sebastien Stephens, Robert Bourke, Peter Heiner, Qin Liu
Qin Liu
Transplanted Retinal Pigment Epithelium(RPE) cells hold promise for treatment of Age-related Macular Degeneration(AMD) and Stargardt Disease(SD), but it is conceivable that the degenerated host Bruch's membrane(BM) as a natural substrate for RPE might not optimally support transplanted cell survival with correct cellular organization. We fabricated novel ultrathin 3-dimensional(3D) nanofibrous membranes from Collagen type I and poly(lactic-co-glycolic acid) (PLGA) by an advanced clinical-grade needle-free-electrospinning process. The nanofibrillar 3D networks highly mimicked the fibrillar architecture of the native inner collagenous layer of human BM. Human RPE cells grown on our nanofibrous membranes bore striking resemblance to native human RPE. They exhibited a …
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
Edward R Norris MD, FAPA, FAPM
No abstract provided.
Relationship Between Plasma Glucose And Mortality In Non-Diabetic Patients With Acute Coronary Syndrome And Systolic Heart Failure: Insights From The Ephesus Trial, Prakash Deedwania Md, Ravi V. Desai Md, Marjan Mujib Md, Mph, Bertram Pitt, Ali Ahmed Md, Mph
Relationship Between Plasma Glucose And Mortality In Non-Diabetic Patients With Acute Coronary Syndrome And Systolic Heart Failure: Insights From The Ephesus Trial, Prakash Deedwania Md, Ravi V. Desai Md, Marjan Mujib Md, Mph, Bertram Pitt, Ali Ahmed Md, Mph
Ravi V Desai MD
No abstract provided.
Differential Association Of Insulin Resistance And Metabolic Syndrome With Acute Myocardial Infarction And All-Cause Mortality In Older Adults, Ravi Desai, Mustafa Ahmed, Marjan Mujib, Larry Jacobs, Gregg Fonarow, Gilbert Perry, Wilbert Aronow, Michael Zile, Ali Ahmed
Differential Association Of Insulin Resistance And Metabolic Syndrome With Acute Myocardial Infarction And All-Cause Mortality In Older Adults, Ravi Desai, Mustafa Ahmed, Marjan Mujib, Larry Jacobs, Gregg Fonarow, Gilbert Perry, Wilbert Aronow, Michael Zile, Ali Ahmed
Ravi V Desai MD
No abstract provided.
The Association Of Metabolic Syndrome And Insulin Resistance With Incident Heart Failure Is Independent Of Each Other And Other Risk Factors Including C-Reactive Protein, Ravi V. Desai Md, Prakash Deedwania Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Yan Zhang Ms, Msph, Wilbert S. Aronow Md, Gregg C. Fonarow Md, Ali Ahmed Md, Mph
The Association Of Metabolic Syndrome And Insulin Resistance With Incident Heart Failure Is Independent Of Each Other And Other Risk Factors Including C-Reactive Protein, Ravi V. Desai Md, Prakash Deedwania Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Yan Zhang Ms, Msph, Wilbert S. Aronow Md, Gregg C. Fonarow Md, Ali Ahmed Md, Mph
Ravi V Desai MD
No abstract provided.
Is The Association Of Left Ventricular Geometry With Cardiovascular Outcomes Independent Of Left Ventricular Mass?, Ravi V. Desai Md, Marjan Mujib Md, Mph, Mustafa I. Ahmed Md, Larry E. Jacobs Md, Gregg C. Fonarow, Wilbert S. Aronow, Michael Zile Md, Ali Ahmed
Is The Association Of Left Ventricular Geometry With Cardiovascular Outcomes Independent Of Left Ventricular Mass?, Ravi V. Desai Md, Marjan Mujib Md, Mph, Mustafa I. Ahmed Md, Larry E. Jacobs Md, Gregg C. Fonarow, Wilbert S. Aronow, Michael Zile Md, Ali Ahmed
Ravi V Desai MD
No abstract provided.
Effect Of Left Ventricular Diastolic Dysfunction On Incident Heart Failure And Mortality Is Independent Of Left Ventricular Geometry, Mass And Systolic Function, Ravi V. Desai Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Larry E. Jacobs Md, Gregg Fonarow Md, Gilbert J. Perry, Wilbert S. Aronow Md, Michael Zile Md, Ali Ahmed Md, Mph
Effect Of Left Ventricular Diastolic Dysfunction On Incident Heart Failure And Mortality Is Independent Of Left Ventricular Geometry, Mass And Systolic Function, Ravi V. Desai Md, Mustafa I. Ahmed Md, Marjan Mujib Md, Mph, Larry E. Jacobs Md, Gregg Fonarow Md, Gilbert J. Perry, Wilbert S. Aronow Md, Michael Zile Md, Ali Ahmed Md, Mph
Ravi V Desai MD
No abstract provided.
Cultural Adaptation Of The Hiv Felt Stigma Scale For Puerto Ricans With Hiv In Allentown, Pa, Julio Jiménez Md, Joseph L. Yozviak Do, Facp, Timothy J. Friel Md, D Adams Psyd, Cynthia Beitler, Eric J. Gertner Md, Mph, E Rivera Ba, M Reyes Ba, L Santiago Phd
Cultural Adaptation Of The Hiv Felt Stigma Scale For Puerto Ricans With Hiv In Allentown, Pa, Julio Jiménez Md, Joseph L. Yozviak Do, Facp, Timothy J. Friel Md, D Adams Psyd, Cynthia Beitler, Eric J. Gertner Md, Mph, E Rivera Ba, M Reyes Ba, L Santiago Phd
Joseph L Yozviak DO, FACP
No abstract provided.
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
A Multidisciplinary, Resident-Run Clinic For The Treatment Of Hepatitis C In An Underserved, Urban Primary Care Setting, Suzanne J. Templer Do, Joseph L. Yozviak Do, Facp, Vishal Patel Md, Edward Norris Md, Fapm, Eric J. Gertner Md, Mph
Joseph L Yozviak DO, FACP
No abstract provided.
Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, J Mannino, Sharon R. Kimmel Phd, Mha
Formula Using Routine Biochemical Markers Proved Superior To Forn's And Apri In Predicting Early Vs. Late-Stage Liver Disease In The Hiv/Hcv Co-Infected Host, Margaret Hoffman-Terry Md, Facp, Joseph L. Yozviak Do, Facp, J Mannino, Sharon R. Kimmel Phd, Mha
Joseph L Yozviak DO, FACP
No abstract provided.
Right Ventricular Mass Index Predicts Pulmonary Vascual Resistance In Pulmonary Vascular Pulmonary Arterial Hypertension: Baseline Cardiac Mri Results Of The Compass-3 Trial, Himanshu Gupta, Ravi Desai, Steven Lloyd, Fernando Orres, Francisco Soto, Myung Park, Chad Mcqueen, Srinivas Murali, Raymond Benza
Right Ventricular Mass Index Predicts Pulmonary Vascual Resistance In Pulmonary Vascular Pulmonary Arterial Hypertension: Baseline Cardiac Mri Results Of The Compass-3 Trial, Himanshu Gupta, Ravi Desai, Steven Lloyd, Fernando Orres, Francisco Soto, Myung Park, Chad Mcqueen, Srinivas Murali, Raymond Benza
Ravi V Desai MD
No abstract provided.
Torsional Modulus: A Simple, Novel Index Of Ventricular Stiffness, Steven Lloyd, Ravi Desai, Thomas Denney, Himanshu Gupta, Mustafa Ahmed, Louis Dell'italia
Torsional Modulus: A Simple, Novel Index Of Ventricular Stiffness, Steven Lloyd, Ravi Desai, Thomas Denney, Himanshu Gupta, Mustafa Ahmed, Louis Dell'italia
Ravi V Desai MD
No abstract provided.
Encyclopedia Of Animal Behavior, A. Payne, P. Starks, Aviva Liebert
Encyclopedia Of Animal Behavior, A. Payne, P. Starks, Aviva Liebert
Aviva E Liebert
The Encyclopedia of Animal Behavior has engaged-with great success-the efforts of many of the best behavioral biologists of the 21st century. Section editors drawn from the most accomplished behavioral scientists of their generation have enrolled an international cast of highly respected thinkers and writers-all of whom have taken great care and joy in illuminating every imaginable corner of animal behavior. This comprehensive work covers not only the usual topics such as communication, learning, sexual selection, navigation, and the history of the field, but also emerging topics in cognition, animal welfare, conservation, and applications of animal behavior. The large section on …
Pathways To Psychosis In Cannabis Abuse, Amresh Srivastava
Pathways To Psychosis In Cannabis Abuse, Amresh Srivastava
Amresh Srivastava
Cannabis has been implicated as a risk factor for the development of schizophrenia, but the exact biological mechanisms remain unclear. In this review, we attempt to understand the neurobiological pathways that link cannabis use to schizophrenia. This has been an area of great debate; despite similarities between cannabis users and schizophrenia patients, the evidence is not sufficient to establish cause-and-effect. There have been advances in the understanding of the mechanisms of cannabis dependence as well as the role of the cannabinoid system in the development of psychosis and schizophrenia. The neurobiological mechanisms associated with the development of psychosis and effects …
Stroma-Dependent Development Of Two Dendritic-Like Cells Types With Distinct Antigen Presenting Capability, Pravin Periasamy, Helen O'Neill
Stroma-Dependent Development Of Two Dendritic-Like Cells Types With Distinct Antigen Presenting Capability, Pravin Periasamy, Helen O'Neill
Helen O'Neill
Dendritic cells (DC) represent a heterogeneous class of antigen presenting cells (APC). Previously we reported a distinct myeloid dendritic-like cell present in spleen, as an in vivo counterpart to cells produced in murine spleen long-term cultures (LTC-DC). These cells, named 'L-DC', were found to be functionally and phenotypically distinct from conventional (c)DC, plasmacytoid (p)DC and monocytes. These results suggested that spleen may represent a niche for development of L-DC from endogenous progenitors. Adult murine spleen has now been investigated for the presence of L-DC progenitors. Lineage-negative (Lin)-ckitlo and Lin-ckithi progenitor subsets were identified as candidate populations, and tested for ability …
Distinct Progenitor Origin Distinguishes A Lineage Of Dendritic-Like Cells In Spleen., Sawang Petvises, Helen O'Neill
Distinct Progenitor Origin Distinguishes A Lineage Of Dendritic-Like Cells In Spleen., Sawang Petvises, Helen O'Neill
Helen O'Neill
The dendritic cell (DC) compartment comprises subsets of cells with distinct phenotypes. Previously this lab reported methodology for hematopoiesis of dendritic-like cells in vitro dependent on a murine splenic stromal cell line (5G3). Co-cultures of lineage-depleted bone marrow (Lin- BM) over 5G3 continuously produced a distinct population of dendritic-like "L-DC" for up to 35 days. Here the progenitor of L-DC is investigated in relation to known BM-derived hematopoietic progenitors. It is shown here that L-DC-like cells also derive from the CD150+Flt3- long-term reconstituting-hematopoietic stem cells (HSC), and also from the Flt3+ multipotential progenitor subset in BM. Lin- BM co-cultures also …
Novel Splenic Antigen Presenting Cell Derive From A Lin-Ckitlo Progenitor, Pravin Periasamy, Jonanthan Tan, Helen O'Neill
Novel Splenic Antigen Presenting Cell Derive From A Lin-Ckitlo Progenitor, Pravin Periasamy, Jonanthan Tan, Helen O'Neill
Helen O'Neill
The main DC subsets in murine spleen arise from BMderived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin-c-kitlo hematopoietic progenitor and is most highly enriched among the Lin-c-kitloCD34+ subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8+ T cells but not CD4+ T cells.