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Gadd45Γ Mediates The Activation Of The P38 And Jnk Map Kinase Pathways And Cytokine Production In Effector Th1 Cells, Binfeng Lu, Hong Yu, Chi-Wing Chow, Baiyong Li, Wei-Ping Zeng, Roger Davis, Richard Flavell

Wei-ping Zeng

The p38 and JNK stress-activated MAPK signal transduction pathways are activated by T cell receptor (TCR) signaling and are required for IFN-γ production by T_H1 effector cells. Here, we show that the expression of GADD45γ is induced during T cell activation and that the level of expression is higher in T_H1 cells than in T_H2 cells. T_H1 cells from GADD45γ^−/− mice are severely compromised in their abilities to activate p38 and JNK in response to TCR signaling, produce much less IFN-γ upon restimulation, and are deficient in activation-induced cell death (AICD). …