Medicine and Health Sciences Commons^™

Folate Network Genetic Variation, Plasma Homocysteine, And Global Genomic Methylation Content: A Genetic Association Study, Susan M. Wernimont, Andrew G. Clark, Patrick J. Stover, Martin T. Wells, Augusto A. Litonjua, Scott T. Weiss, J. Michael Gazianno, Katherine L. Tucker, Andrea Baccarelli, Joel Schwartz, Valentina Bollati, Patricia A. Cassano

Katherine L. Tucker

Background

Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease.

Methods

330 SNPs in 52 genes were studied in relation to plasma homocysteine and global genomic DNA methylation. SNPs were selected based on functional effects and gene coverage, and assays were completed on the Illumina Goldengate platform. Age-, smoking-, and nutrient-adjusted genotype--phenotype associations were estimated in regression models.

Results

Using a nominal P ≤ 0.005 threshold for statistical significance, 20 SNPs were associated with plasma homocysteine, 8 …

Effects Of Two Different Doses Of Acetylsalicylic Acid On Serum Nitric Oxide, Asymmetric Dimethylarginine, And Homocysteine Levels In Healthy Volunteers*, İdri̇s Mehmetoğlu, Sevi̇l Kurban

Turkish Journal of Medical Sciences

To examine the effects of ASA on serum nitric oxide (NO), asymmetric dimethylarginine (ADMA), and homocysteine levels in healthy volunteers. Materials and methods: Totally, 26 apparently healthy volunteers were enrolled in the study. Of the participants, 13 (5F, 8M) received 100 mg of ASA daily and 13 (5F, 8M) received 150 mg of ASA daily for 2 months. Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months after ASA treatment. Results: ADMA levels of the group receiving 150 …

Serum Nitric Oxide, Asymmetric Dimethylarginine, And Plasma Homocysteine Levels In Active Behçet's Disease, Murat Aydin, Cemi̇le Koca, Sema Uysal, Yüksel Totan, Ramazan Yağci, Ferah Armutcu, Zübeyde Cücen, Muhammet Ramazan Yi̇ği̇toğlu

Turkish Journal of Medical Sciences

Behçet's disease is a relapsing vasculitis characterized by endothelial dysfunction. This study was conducted to determine the levels of nitric oxide (NO) and 2 related parameters, asymmetric dimethylarginine (ADMA) and homocysteine levels, in relation to the pathogenesis of Behçet's disease. Materials and methods: A total of 49 Behçet's patients, comprising 26 patients with the active disease and 23 patients with the inactive disease, and a healthy control group of 24 individuals participated in this study. International Study Group Diagnostic Criteria were followed in the diagnosis of Behçet's disease; patients who had at least 2 signs were considered as having the …

Relation Of Total Homocysteine Level With Metabolic And Anthropometric Variables In Obese Children And Adolescents, Ayhan Abaci, Ahmet Zülfi̇kar Akelma, Osman Özdemi̇r, Şami̇l Hizli, Cem Hasan Razi, Kadi̇r Okhan Akin

Turkish Journal of Medical Sciences

To evaluate the total homocysteine (tHcy) level, a risk factor for atherosclerosis, atherothrombosis, and insulin resistance, for sex and pubertal state differences in obese children. Its relationship with metabolic and anthropometric parameters was also investigated. Materials and methods: The study involved obese children with a body mass index (BMI) above the 95th percentile who presented with the complaint of excessive weight gain, and healthy children with a BMI below the 85th percentile. Results: The study included 100 obese (mean age: 10.2 ± 2.7 years) and 71 healthy nonobese (mean age: 10.9 ± 2.6) children. A comparison of the data from …