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Full-Text Articles in Medicine and Health Sciences
Systematic Review Of Tst Responses In People Living With Hiv In Under-Resourced Settings: Implications For Isoniazid Preventive Therapy., Andrew D. Kerkhoff, Katharina Kranzer, Taraz Samandari, Jessica Nakiyingi-Miiro, Christopher C. Whalen, Anthony D. Harries, Stephen D. Lawn
Systematic Review Of Tst Responses In People Living With Hiv In Under-Resourced Settings: Implications For Isoniazid Preventive Therapy., Andrew D. Kerkhoff, Katharina Kranzer, Taraz Samandari, Jessica Nakiyingi-Miiro, Christopher C. Whalen, Anthony D. Harries, Stephen D. Lawn
Microbiology, Immunology, and Tropical Medicine Faculty Publications
Background
People living with HIV (PLWH) who have positive tuberculin skin tests (TST) benefit from isoniazid preventive therapy (IPT) whereas those testing TST-negative do not. Revised World Health Organization guidelines explicitly state that assessment of TST is not a requirement for initiation of IPT. However, it is not known what proportions of patients will benefit from IPT if implemented without targeting according to TST status. We therefore determined the proportions of PLWH who test TST-positive.
Methodology/Principal Findings
We systematically reviewed the literature published between January 1990 and February 2012 to determine the proportions of patients without active tuberculosis attending HIV …