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- BINDING AFFINITY (1)
- Drosophila (1)
- Glucocorticoids (1)
- HIPPOCAMPUS (1)
- Hox genes (1)
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- INTRACELLULAR SIGNALLING (1)
- Neuronal segment patterning (1)
- Nonlinear Mixed Effects Modeling (1)
- PRENATAL DEXAMETHASONE (1)
- Prenatal Dexamethasone (1)
- RADIOLIGAND RECEPTOR BINDING ASSAYS (1)
- RECEPTOR DENSITY (1)
- Randomization Test (1)
- SEROTONIN 1A RECEPTOR (1)
- Stress Challenge (1)
- Ventral nervous system development (1)
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Spatial Learning And Stress Response Of Male Rats Prenatally Exposed To Dexamethasone, Joseph John Donohoe
Spatial Learning And Stress Response Of Male Rats Prenatally Exposed To Dexamethasone, Joseph John Donohoe
Master’s Theses
Dexamethasone is routinely administered to women at risk for a preterm birth in order to enhance fetal lung development and reduce uterine contractions. Research has demonstrated possible behavioral abnormalities in adulthood as a result of dexamethasone treatment. Using nonlinear mixed effects modeling, this study found thatprenatal dexamethasone treatment impaired spatial learning and memory of adult male Sprague-Dawley rats. Prenatal dexamethasone treatment also led to more anxiety related behaviors on Elevated Plus Maze testing 1.5 hours after a stress challenge. Because theassumptions underlying the independent samples t-test were violated, the randomization test was used to compare groups on the Elevated Plus …
Effects Of Prenatal Dexamethasone On Hipopcampal Serotonin 1a Receptors In Adult Male Rats, Rahul Vijay
Effects Of Prenatal Dexamethasone On Hipopcampal Serotonin 1a Receptors In Adult Male Rats, Rahul Vijay
Master’s Theses
The main activation route for the stress response is the hypothalamo-pituitaryadrenal axis (HPA) and the sympatho-adrenomedullary system. The HPA axis is a neuroendocrine feedback loop mediated by an array of tissue specific hormones, receptors and neurotransmitters that regulate glucocorticoid (GC) release. GCs are steroidal hormones produced by the adrenal glands and are key players in a negativefeedback loop controlling HPA activity. They influence the HPA axis through glucocorticoid receptors in the hypothalamus and pituitary and through both glucocorticoid (GR) and mineralcorticoid receptors (MR) that are co-localized in the hippocampus. Repeated or chronic stress exerts a negative influence on these HPA …
The Overexpression Of Homeotic Complex Gene Ultrabithorax In The Post-Embryonic Neuronal Lineages Of The Ventral Nervous System In Drosophila Melanogaster, Katie Dry
Master’s Theses
This study uses a molecular technique called MARCM (Mosaic Analysis with a Repressible Cell Marker) to label neuronal lineages that overexpress the Hox gene Ultrabithorax (Ubx) in an unlabeled, wild type background. The results indicate that the overexpression of Ubx is sufficient to transform more anterior neuronal lineages to themorphology of their more posterior counterparts. The data presented here begin to elucidate the role that the Hox genes have in shaping segment-specific neural connections in the post-embryonic ventral nervous system.