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Effects Of Dose, Administration Route And/Or Vehicle On Decabromodiphenyl Ether (Decabde) Concentrations In Plasma Of Maternal, Fetal And Neonatal Rats And In Milk Of Maternal Rats, J. A. Biesemeier, Melissa J. Beck, H. Silberberg, N. R. Myers, J. M. Ariano, E. S. Bodle, D. W. Sved, S. Jacobi, D. G. Stump, M. Hardy, T. Stedeford
Effects Of Dose, Administration Route And/Or Vehicle On Decabromodiphenyl Ether (Decabde) Concentrations In Plasma Of Maternal, Fetal And Neonatal Rats And In Milk Of Maternal Rats, J. A. Biesemeier, Melissa J. Beck, H. Silberberg, N. R. Myers, J. M. Ariano, E. S. Bodle, D. W. Sved, S. Jacobi, D. G. Stump, M. Hardy, T. Stedeford
Pharmaceutical Sciences Faculty Publications
The effects of route and vehicle on blood and milk levels of decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) were investigated in the rat to assist in the design and conduct of a developmental neurotoxicity study. Blood plasma and/or milk concentrations were determined in dams, fetuses, and/or nursing pups after repeated DecaBDE administration by gavage throughout gestation or gestation and lactation using corn oil (CO) or soyaphospholipon/Lutrol F 127-water (SPL) as the vehicle. The impact of vehicle on plasma levels was also investigated in pups derived from naive dams after a single postnatal dose. This study reports for the first time fetal …