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Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation, Claudio Alberto Villalobos
Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation, Claudio Alberto Villalobos
Wayne State University Dissertations
One of the most characteristic features of pyramidal cells in the prefrontal cortex (PFC) is that they present a slow afterhyperpolarizing current (IsAHP) that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via GΑq/11 G proteins, thus it is thought that neurotransmitters regulate neuronal excitability through the inhibition of this current. IsAHP is known to be mediated by calcium-activated potassium channels, however, neither the identity of the channel underlying this current nor its mechanism of activation are yet well understood. Recent reports have questioned a direct role …