Medicine and Health Sciences Commons^™

Fluprostenol-Induced Mapk Signaling Is Independent Of Aging In Fischer 344/Nniahsd X Brown Norway/Binia Rat Aorta, Kevin M. Rice, Ernest M. Walker, Sunil K. Kakarla, Satyanarayana Paturi, Miaozong Wu, Sumit Narula, Eric R. Blough

MIIR Faculty Research

The factors that regulate vascular mechanotransduction and how this process may be altered with aging are poorly understood and have not been widely studied. Recent data suggest that increased tissue loading can result in the release of prostaglandin F2 alpha (PGF2α) and other reports indicate that aging diminishes the ability of the aged aorta to activate mitogen activated protein kinase (MAPK) signaling in response to increased loading. Using ex vivo incubations, here we investigate whether aging affects the ability of the aorta to induce phosphorylation of extracellular signal-regulated kinase 1/2 (ERK½-MAPK), p38-MAPK, and Jun N-terminal kinase (JNK-MAPK) activation following stimulation …