Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Retinoic Acid Induced 1 Gene Analysis In Humans And Zebrafish, Bijal Vyas
Retinoic Acid Induced 1 Gene Analysis In Humans And Zebrafish, Bijal Vyas
Theses and Dissertations
Smith-Magenis syndrome (SMS) is a complex mental retardation syndrome caused by deletion of 17p11.2 region or mutation of the RAI1 gene (retinoic acid induced 1). Individuals with SMS typically exhibit speech and motor delays, mental retardation, characteristic craniofacial and skeletal anomalies, and a distinct neurobehavioral phenotype that includes sleep disturbances, stereotypes, and maladaptive and self-injurious behaviors. RAI1 is thought to be a transcription factor modulating the expression of genes involved in a variety of cellular functions. Previous studies have shown the RAI1 gene being induced by retinoic acid (RA), a derivative of vitamin A. RA plays a significant role in …
Associations Between Low Back Pain, Disability, Functional Status, And Serum Interleukin-1 \Beta Level, Ali̇ Aydeni̇z, Teki̇n Karsligi̇l, Savaş Gürsoy
Associations Between Low Back Pain, Disability, Functional Status, And Serum Interleukin-1 \Beta Level, Ali̇ Aydeni̇z, Teki̇n Karsligi̇l, Savaş Gürsoy
Turkish Journal of Medical Sciences
Aim: In the past the role of biochemical mediators of inflammation in back pain received little attention. The purpose of the present study was to examine the association between serum IL-1 \beta level in patients with low back pain (LBP) and its effect on their functional status. Methods: This cross-sectional study included 88 LBP patients with symptom duration of 6 months or longer and 65 healthy controls. Serum analysis was performed using ELISA. The LBP group completed the Roland-Morris Disability Questionnaire and Oswestry Disability Index in order to evaluate their functional status. Results: Mean IL-1 \beta level was significantly higher …