Medicine and Health Sciences Commons^™

High-Resolution Physical Map For Chromosome 16q12.1-Q13, The Blau Syndrome Locus., Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams, Gerard Tromp

Charlene Williams

BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, …

Risk Factors Affecting Surgical Outcomes In Patients Undergoing Hypothermic Circulatory Arrest During Aortic Surgeries: A 10-Year Study, Bree Ann Young, James K. Wu, Martin E. Matsumura Md, Sanjay M. Mehta Md, Theodore G. Phillips Md, Michael F. Szwerc Md, Gary W. Szydlowski Md, Raymond L. Singer Md

Raymond L Singer MD

No abstract provided.

An Uncommon Complication During Trans-Aortic Valve Replacement, Sanjeev Nair Md, Yassir Nawaz Md, Nainesh C. Patel Md, David A. Cox Md, William Combs Md, Raymond L. Singer Md, J Patrick Kleaveland Md

Raymond L Singer MD

No abstract provided.

Trans-Catheter Aortic Valve Replacement: The Future Is Here, Raymond Singer, J Kleaveland

Raymond L Singer MD

No abstract provided.

Outcome Of Traumatic Aortic Rupture: A 14-Year Experience, Matthew Wilson, James K. Wu, Sanjay M. Mehta Md, Theodore G. Phillips Md, Raymond L. Singer Md, Michael F. Szwerc Md, Gary W. Szydlowski Md

Raymond L Singer MD

No abstract provided.

Incidence And Predictors Of Permanent Pacemaker Implantation After Valve Surgery – A Single Center Experience, Justin L. Guthier Do, Bilal Ayub Md, Yassir Nawaz Md, Hassam Saif Md, Robert F. Malacoff Md, Facc, Michael J. Weiss Mph, Theodore G. Phillips Md, James K. Wu Md, Raymond L. Singer Md, Sanjay M. Mehta Md, Gary W. Szydlowski Md, Ronald S. Freudenberger Md

Raymond L Singer MD

No abstract provided.

Septal Myectomy In Obstructive Hypertrophic Cardiomyopathy High Risk Patients, Heather Geist, Matthew W. Martinez Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Incidence And Predictors Of Permanent Pacemaker Implantation After Valve Surgery – A Single Center Experience, Justin L. Guthier Do, Bilal Ayub Md, Yassir Nawaz Md, Hassam Saif Md, Robert F. Malacoff Md, Facc, Michael J. Weiss Mph, Theodore G. Phillips Md, James K. Wu Md, Raymond L. Singer Md, Sanjay M. Mehta Md, Gary W. Szydlowski Md, Ronald S. Freudenberger Md

James K. Wu, M.D.

No abstract provided.

Outcomes Of Comatose Cardiac Arrest Survivors With And Without St-Segment Elevation Myocardial Infarction: Importance Of Coronary Angiography., Karl B Kern, Kapildeo Lotun, Nainesh Patel, Michael R Mooney, Ryan D Hollenbeck, John A Mcpherson, Paul W Mcmullan, Barbara Unger, Chiu-Hsieh Hsu, David B Seder

Nainesh C Patel MD

OBJECTIVES: The aim of this study was to compare outcomes and coronary angiographic findings in post-cardiac arrest patients with and without ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The 2013 STEMI guidelines recommend performing immediate angiography in resuscitated patients whose initial electrocardiogram shows STEMI. The optimal approach for those without STEMI post-cardiac arrest is less clear. METHODS: A retrospective evaluation of a post-cardiac arrest registry was performed. RESULTS: The database consisted of 746 comatose post-cardiac arrest patients including 198 with STEMI (26.5%) and 548 without STEMI (73.5%). Overall survival was greater in those with STEMI compared with those without (55.1% vs. …

Medical Hypothermia Post Cardiac Arrest, Nainesh Patel, John Castaldo, Ronald Freudenberger, Sudip Nanda

Nainesh C Patel MD

No abstract provided.

Septal Myectomy In Obstructive Hypertrophic Cardiomyopathy High Risk Patients, Heather Geist, Matthew W. Martinez Md, James K. Wu Md

Matthew W Martinez MD

No abstract provided.

Rapid Door-To-Balloon Time (≤ 30 Minutes) In The Treatment Of Acute St-Elevation Myocardial Infarction (Stemi) Is Associated With Reduced Length Of Hospital Stay And Improved Clinical Outcomes, Yassir Nawaz Md, Ataul Qureshi Md, Navin K. Subrayappa Md, Orlando E. Rivera Rn, Bruce Feldman Do, Nainesh C. Patel Md

Bruce A. Feldman DO

No abstract provided.

Risk Of Heart Failure And Death After Prolonged Smoking Cessation: Role Of Amount And Duration Of Prior Smoking., Amiya A Ahmed, Kanan Patel, Margaret A Nyaku, Raya E Kheirbek, Vera Bittner, Gregg C Fonarow, Gerasimos S Filippatos, Charity J Morgan, Inmaculada Aban, Marjan Mujib, Ravi Desai, Richard M Allman, Michel White, Prakash Deedwania, George Howard, Robert O Bonow, Ross D Fletcher, Wilbert S Aronow, Ali Ahmed

Ravi V Desai MD

BACKGROUND: -According to the 2004 Surgeon General's Report on Health Consequences of Smoking, after >15 years of abstinence, the cardiovascular risk of former smokers becomes similar to that of never-smokers. Whether this health benefit of smoking cessation varies by amount and duration of prior smoking remains unclear.

METHODS AND RESULTS: -Of the 4482 adults ≥65 years without prevalent heart failure (HF) in the Cardiovascular Health Study (CHS), 2556 were never-smokers, 629 current smokers, and 1297 former smokers with >15 years of cessation, of whom 312 were heavy smokers (highest quartile; ≥32 pack-years). Age-sex-race-adjusted hazard ratios (aHR) and 95% confidence intervals …

Ectopic Cushing Syndrome And Pancreatic Cancer: A Case Report, Mira Mitry Md, Nicole M. Agostino Do, Stacey Smith Md, Facp, Vasudev G. Magaji Md, Ms

Vasudev G Magaji MD, MS

No abstract provided.

Mifepristone Utilization In Cushing’S From Large Bilateral Adrenal Adenoma Prior To Surgery, Vasudev Magaji, Sarah Park, Katie Mastoris, Maura Bucciarelli, Scott Beman

Vasudev G Magaji MD, MS

Utilization of mifepristone was described to mitigate hypercortisolism from bilateral adrenal Cushing’s syndrome. A 47-year-old female on abdominal pain evaluation with CT was found to have a 5.4 × 1.7 × 4.9 cm right adrenal nodule and a 4.3 × 2.9 × 3.3 cm left adrenal nodule with calcification on CT scan with each having density of -3 Housefield units. She had hypercortisolism with testing revealing high urine free cortisol, unsuppressed cortisol on 1 mg and 8 mg overnight dexamethasone suppression testing, high 11 pm salivary cortisol × 2 along with elevated random cortisol and undetectable ACTH. Her DHEA-S, plasma …

Use Of An Electronic Medical Record (Emr) To Identify Glycemic Intensification Strategies In Type 2 Diabetes., Mary T Korytkowski, Maria Brooks, Manuel Lombardero, Dilhari Dealmeida, Justin Kanter, Vasudev Magaji, Trevor Orchard, Linda Siminerio

Vasudev G Magaji MD, MS

Current treatment guidelines for type 2 diabetes (T2D) recommend individualized intensification of therapy for glycated hemoglobin (A1C) ≥ 7% in most patients. The purpose of this investigation was to explore the ability of an electronic medical record (EMR) to identify glycemic intensification strategies among T2D patients receiving pharmacologic therapy. Patient records between 2005 and 2011 with documentation of A1C and active prescriptions for any diabetes medications were queried to identify potential candidates for intensification based on A1C ≥ 7% while on 1-2 oral diabetes medications (ODM). Patients with follow-up A1C values within 1 year of index A1C were grouped according …

1,25-Dihydroxyvitamin D-Mediated Hypercalcemia In A Patient With Maligancy Without Lymphoma, Katie Mastoris, Sarah Park, Vasudev Magaji

Vasudev G Magaji MD, MS

No abstract provided.

Mi Alert St-Segment Elevation Myocardial Infarction (Stemi) Real Time Data Feedback: A Patient Quality Of Care Initiative, Orlando Rivera, Nainesh Patel, Bruce Feldman

Nainesh C Patel MD

No abstract provided.

Atrial Fibrillation--Advances In Drug Therapy, Sudip Nanda, Sultan Siddique, Matthew Martinez, Shree Sharma, Nainesh Patel, Santo Longo

Nainesh C Patel MD

No abstract provided.

Early Cardiac Catheterization Is Associated With Improved Survival In Comatose Survivors Of Cardiac Arrest Without Stemi, Ryan Hollenbeck, John Mcpherson, Michael Mooney, Barbara Unger, Nainesh Patel, Paul Mcmullan, Chiu-Hsieh Hsu, David Seder, Karl Kern

Nainesh C Patel MD

AIM: To determine if early cardiac catheterization (CC) is associated with improved survival in comatose patients who are resuscitated after cardiac arrest when electrocardiographic evidence of ST-elevation myocardial infarction (STEMI) is absent.

METHODS: We conducted a retrospective observational study of a prospective cohort of 754 consecutive comatose patients treated with therapeutic hypothermia (TH) following cardiac arrest.

RESULTS: A total of 269 (35.7%) patients had cardiac arrest due to a ventricular arrhythmia without STEMI and were treated with TH. Of these, 122 (45.4%) received CC while comatose (early CC). Acute coronary occlusion was discovered in 26.6% of patients treated with early …

Cardiopulmonary Resuscitation Prescription Program: A Prospective Randomized Pilot Study, Marna Greenberg, Gavin Barr, Valerie Rupp, Nainesh Patel, Kevin Weaver, Kimberly Hamilton, James Reed

Nainesh C Patel MD

No abstract provided.

St-Segment Elevation (Stemi) Real Time Data Feedback –A Process Of Care Initiative, Orlando E. Rivera Rn, Nainesh Patel Md, Bruce Feldman Do, Mercedes Rios-Scott Bs, David M. Richardson Md, J Patrick Kleaveland Md, David A. Cox Md, Ronald S. Freudenberger Md

Nainesh C Patel, MD

No abstract provided.

The Effect Of Shortening Door To Balloon Time (<90 Minutes) In Stemi Patients Transferred From Outside Hospitals, Ataul Qureshi Md, Yassir Nawaz Md, Navin K. Subrayappa Md, Orlando E. Rivera Rn, Nainesh C. Patel Md

Nainesh C Patel MD

No abstract provided.

Therapeutic Medical Hypothermia--A Multispecialty Approach, Sudip Nanda, Nainesh Patel, Surya Bhatt, Claranne Mathiesen, John Castaldo, Shree Sharma, Santo Longo

Nainesh C Patel MD

No abstract provided.

Thrombocytosis And Coronary Occlusion, Amit Nanavati, Nainesh Patel, James Burke

Nainesh C Patel MD

No abstract provided.

Choosing Radial Vs. Femoral Cardiac Catheterization: Does Operator Seniority Matter? A Single Center Experience, Nitin Verma Md, Amit N. Nanavati Md, Justin Roberts Do, Nainesh C. Patel Md

Nainesh C Patel MD

No abstract provided.

Visualization And Management Of A Distally Embolized Stent After St-Elevation Myocardial Infarction, Amit Nanavati Md, Nainesh C. Patel Md

Nainesh C Patel MD

No abstract provided.

Post-Resuscitation Care Practices Following Cardiac Arrest At Six Regional Interventional Cardiology Centers In The United States 2007-2011, David B. Seder Md, Nainesh Patel Md, J Mcpherson, P Mcmullen, K B. Kern, B Unger, J Browning, Sudip Nanda Md, Facp, M Hacobian, M B. Kelley, N Nielsen, M Mooney

Nainesh C Patel, MD

No abstract provided.

An Uncommon Complication During Trans-Aortic Valve Replacement, Sanjeev Nair Md, Yassir Nawaz Md, Nainesh C. Patel Md, David A. Cox Md, William Combs Md, Raymond L. Singer Md, J Patrick Kleaveland Md

Nainesh C Patel, MD

No abstract provided.

Door To Balloon Times Less Than 30 Minutes: The Lehigh Valley Health Network (Lvhn) Experience, M Sarkees, Matthew Martinez, Bruce Feldman, J Kleaveland, Orlando Rivera, Michael Rossi, William Combs, David Cox, Ronald Freudenberger, Nainesh Patel

Nainesh C Patel MD

No abstract provided.